As part of the Survey of Painters and Repairers of Auto bodies by Yale (SPRAY), the determinants of isocyanate exposure in auto body repair shops were evaluated. Measurements (n = 380) of hexamethylene diisocyanate-based monomer and polyisocyanate and isophorone diisocyanate-based polyisocyanate were collected from 33 auto body shops. The median total reactive isocyanate concentrations expresse...

During meiosis, DNA double-strand breaks ultimately yield two types of recombinants: crossovers (CO) and noncrossovers (NCO). Recent studies in budding yeast show the CO/NCO designation occurs before stable strand exchange and thus well before Holliday junction resolution. Chromosome synapsis occurs after CO/NCO designation and is not required for the regulated distribution of COs along chromos...

We present a method for automatically segmenting the blood vessels in optic nerve head (ONH) centered spectral-domain optical coherence tomography (SD-OCT) volumes, with a focus on the ability to segment the vessels in the region near the neural canal opening (NCO). The algorithm first pre-segments the NCO using a graph-theoretic approach. Oriented Gabor wavelets rotated around the center of th...

We report herein that the terminal nitride complex Na[NV(N[t-Bu]Ar)(3)] (Na[1-VN], Ar = 3,5-Me(2)C(6)H(3)) reacts with CO over the course of 24 h to generate V(N[t-Bu]Ar)(3) (1-V) and sodium cyanate in an isolated yield of 77%. The reaction products were identified using a combination of NMR and IR spectroscopy, and cyanate formation was further confirmed by performing a (13)C labeling experime...

Implementing transformational change towards the Net-Centric Operations (NCO) vision in support of enhanced command and control presents technical, operational, and cultural challenges. The technical challenges are being addressed by both industry and the Department of Defense pushing the state of the art further ahead. However, in many cases the technology transformation is too far ahead of th...

In dynamic optimization problems, the optimal input profiles are typically obtained using models that predict the system behavior. In practice, however, process models are often inaccurate, and on-line model adaptation is required for appropriate prediction and re-optimization. In most dynamic real-time optimization schemes, the available measurements are used to update the plant model, with un...

Adult T-cell leukaemia/lymphoma (ATL) is an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukaemia virus (HTLV)-1. The identification of new molecular targets for ATL prevention and treatment is desired. SIRT1, a nicotinamide adenine dinucleotide(+) -dependent histone/protein deacetylase, plays crucial roles in various physiological processes, including...

PURPOSE OF REVIEW Neonatal corneal opacification (NCO) describes the loss of corneal transparency at or soon after (<4 weeks) birth. Historically, the literature is strewn with terminology that has been at best misleading and at worst, a hindrance to selecting the appropriate treatment plan for, accurate genotype-phenotype correlation of and a better understanding of the entities that present i...

The netCDF Operator (NCO) software facilitates manipulation and analysis of gridded 2 geoscience data stored in the self-describing netCDF format. NCO is optimized to efficiently 3 analyze large multi-dimensional datasets spanning many files. Researchers and data centers 4 often use NCO to analyze and serve observed and modeled geoscience data including satel5 lite observations and weather, air...

Standard structural methods for the assessment of glaucoma, such as the planimetry of stereo color photographs of the optic disc, involve a subjective component either by the patient or examiner and suffer from poor reproducibility. Spectral-domain optical coherence tomography (SD-OCT) provides a 3-D, cross-sectional, microscale depiction of biological tissues. Given the wealth of volumetric in...