نتایج جستجو برای: neighbor on path nop

تعداد نتایج: 8466328  

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011
Yasuyuki Kimura Masahiro Fujita Jinsoo Hong Talakad G Lohith Robert L Gladding Sami S Zoghbi Johannes A Tauscher Nancy Goebl Karen S Rash Zhaogen Chen Concepcion Pedregal Vanessa N Barth Victor W Pike Robert B Innis

UNLABELLED Our laboratory developed (S)-3-(2'-fluoro-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide ((11)C-NOP-1A), a new radioligand for the nociceptin/orphanin FQ peptide (NOP) receptor, with high affinity (K(i), 0.15 nM) and appropriate lipophilicity (measured logD, 3.4) for PET brain imaging. Here, we assessed the utility of (11)C-NOP-1A ...

Journal: :Peptides 2015
Iris U. Medeiros Chiara Ruzza Laila Asth Remo Guerrini Pedro R.T. Romão Elaine C. Gavioli Girolamo Calo

Nociceptin/orphanin FQ is the natural ligand of a Gi-protein coupled receptor named NOP. This peptidergic system is involved in the regulation of mood states and inflammatory responses. The present study aimed to investigate the consequences of blocking NOP signaling in lipopolysaccharide (LPS)-induced sickness and depressive-like behaviors in mice. LPS 0.8mg/kg, ip, significantly induced sickn...

2014
Tomislav Vukina Kenneth Anderson Mary K. Muth

In a recent paper, Vukina et al. [1] analyzed the economic effect of proposed changes in living conditions for laying hens under the USDA National organic Program (NOP), which is administered by the USDA, Agriculture Marketing Service. In addition to proposed changes in living conditions for laying hens, the NOP has proposed changes for organic broilers. With the potential changes in the requir...

2013
LU LI LEI DONG SHENHAO WANG

Nociceptin/orphanin FQ (N/OFQ) and the N/OFQ peptide (NOP) receptor play important roles in regulating gastrointestinal function. To assess whether the NOP receptor is implicated in the etiopathogenesis of irritable bowel syndrome (IBS), we measured the levels of NOP receptor mRNA and protein in the jejunal and colonic tissues of healthy subjects and patients with diarrhea-predominant IBS (D-IB...

Journal: :Pharmacological reviews 2016
Lawrence Toll Michael R Bruchas Girolamo Calo' Brian M Cox Nurulain T Zaveri

The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently discovered member of the opioid receptor family and, together with its endogenous ligand, N/OFQ, make up the fourth members of the opioid receptor and opioid peptide family. Because of its more recent discovery, an understanding of the cellular and behavioral actions induced by NOP receptor activation are les...

Journal: :Genes & genetic systems 2009
Kazumi Koga Daisuke Ichikawa Hirohide Nambu Tomoko Azuma-Kanoh Naoko Sakai Hiroko Takaki-Kawagoe Satoshi Ozaki Hisashi Ohta

We succeeded in cloning the rhesus monkey nociceptin/orphanin FQ peptide (NOP) receptor. The nucleotide sequence and amino acid sequence of the rhesus monkey NOP receptor were 95.9% and 97.8%, respectively, identical to the human NOP receptor. There was no significant difference between the rhesus monkey NOP receptor and the human NOP receptor in the binding affinity of [(125)I] [Thy(14)]nocice...

Journal: :The Journal of pharmacology and experimental therapeutics 2012
Colette M Cremeans Erin Gruley Donald J Kyle Mei-Chuan Ko

Buprenorphine is known as a μ-opioid peptide (MOP) receptor agonist, but its antinociception is compromised by the activation of nociceptin/orphanin FQ peptide (NOP) receptors in rodents. The aim of this study was to investigate the roles of MOP and NOP receptors in regulating buprenorphine-induced physiological responses in primates (rhesus monkeys). The effects of MOP antagonist (naltrexone),...

2013
Lan Zhang Frank Stuber Ulrike M. Stamer

BACKGROUND Nociceptin/orphanin FQ and its receptor (NOP) are involved in immune responses, inflammation and pain processing. The aim of this study was to investigate the modulation of NOP and prepro-nociceptin (PNoc), the precursor of nociceptin, by inflammatory mediators in human whole blood. METHODS Peripheral blood from healthy volunteers was cultured for 0, 3, 6 and 24 hrs with or without...

Journal: :The international journal of neuropsychopharmacology 2011
Yan-Yu Liao Shu-Fang Teng Li-Chun Lin Sabine Kolczewski Eric P Prinssen Li-Jen Lee Ing-Kang Ho Lih-Chu Chiou

The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a non-opioid branch of the opioid receptor family implicated in several neurological and psychological disorders, such as pain, anxiety, depression, involuntary movement, addiction, seizure and dementia. Heterogeneity of NOP receptors has been proposed based on the findings of splicing variants and from binding and functional studies....

Journal: :Journal of animal science 2015
A Romero-Perez E K Okine S M McGinn L L Guan M Oba S M Duval M Kindermann K A Beauchemin

The objective was to evaluate whether long-term addition of 3-nitrooxypropanol (NOP) to a beef cattle diet results in a sustained reduction in enteric CH4 emissions in beef cattle. Eight ruminally cannulated heifers (637 ± 16.2 kg BW) were used in a completely randomized design with 2 treatments: Control (0 g/d of NOP) and NOP (2 g/d of NOP). Treatments were mixed by hand into the total mixed r...

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