The incidence of nephrocalcinosis in very low birthweight (less than 1500 g) premature infants was assessed by ultrasound scan and analysis of urine. Three of 36 infants had nephrocalcinosis. All had been receiving long term frusemide for bronchopulmonary dysplasia with simultaneous fluid restriction. Urinary investigations showed no consistent findings in babies with nephrocalcinosis.

BACKGROUND Experimental data indicate that microscopic calcium phosphate deposition in the kidney (nephrocalcinosis) may accelerate progression of chronic kidney disease (CKD). Data on the prevalence, risk factors and implications of nephrocalcinosis in CKD patients are scarce. A mineral metabolism disorder could play an important pathogenetic role, as suggested by recent protocol biopsy findin...

Aims: Nephrolithiasis and nephrocalcinosis are progressive diseases that can lead to renal impairment. The aim of this analysis was to evaluate aetiological factors, metabolic screening, diagnostic algorithm, treatment, prophylactic measures and follow-up in children with nephrolithiasis and nephrocalcinosis. Patients and methods: Retrospective study of 63 children (36 males, 27 females) with n...

Primary/secondary hyperoxalurias involve nephrocalcinosis-related chronic kidney disease (CKD) leading to end-stage kidney disease. Mechanistically, intrarenal calcium oxalate crystal deposition is thought to elicit inflammation, tubular injury and atrophy, involving the NLRP3 inflammasome. Here, we found that mice deficient in NLRP3 and ASC adaptor protein failed to develop nephrocalcinosis, c...

BACKGROUND An association between chronic hyperaldosteronism and medullary nephrocalcinosis has rarely been made, with only a handful of cases described in literature. CASE REPORT We describe five cases of hyperaldosteronism with a long- standing history in whom associated medullary nephrocalcinosis was established. CONCLUSIONS We infer that a chronic hyperaldosteronic status, whether prima...

nephrolithiasis and nephrocalcinosis are common in both term and premature infants who have had difficult neonatal courses.  multiple factors may contribute and being born from a diabetic mother  is one of them. this case is about a neonate with nephrocalcinosis .she is followed to 9months and remained healthy during a 9 month follow up.

The most common form of renal stone disease, calcium nephrolithiasis, is defined as the presentation of a macroscopic concrement of inorganic (calcium phosphate and/or calcium phosphate) and organic material in the renal calyces and/or pelvis, either adhered to the papillae or pelvic urothelium or not. In search of the mechanism underlying calcium nephrolithiasis, in vitro and in vivo studies a...

Nephrocalcinosis may be defined as a generalized increase in the calcium content of the kidneys. This renal calcification may occur at a molecular, microscopic or macroscopic level leading to progressive amounts of renal damage. The major causes include those associated with an increase in urinary levels of calcium, oxalate and phosphate. Under these conditions, urine concentration and supersat...

BACKGROUND/AIMS Calcium homeostasis requires regulated cellular and interstitial systems interacting to modulate the activity and movement of this ion. Disruption of these systems in the kidney results in nephrocalcinosis and nephrolithiasis, important medical problems whose pathogenesis is incompletely understood. METHODS We investigated 25 patients from 16 families with unexplained nephroca...