Aim of the study is to investigate the Nephroprotective activity of ethanolic extract taken from Melia azadirachta leaves, against APAP (Acetaminophen) induced nephrotoxicity. The phytochemical screening was carried out on the leaf extracts of Melia azadirachta, revealed the presence of active ingredients such as Phytol, Squalene, Oleic Acid, 2-Piperidinone, N-[4-bromo-n-butyl]. Leaves of Melia...

This study investigated the nephroprotective effect of curcumin against acetaminophen (APAP)induced nephrotoxicity in rats. APAP-induced nephrotoxicity was evident by a significant increase (P<0.01) of urea and creatinine in serum. Furthermore, a significant increase (P<0.01) of lipid peroxidation as malondialdehyde (MDA), nitric oxide (NO), protein carbonyl (PC) contents, interleukin-1β(IL-1β)...

BACKGROUND The kidney is tasked with a number of metabolic functions in the body. In its role as a detoxifier and primary eliminator of xenobiotics, it becomes vulnerable to developing injuries. Currently, over 1 million people in the world are living on renal replacement therapies (RRTs). The case in sub-Sahara African countries like Nigeria and South Africa is not any better than the global t...

Protective effect of Camellia Sinensis L. leaf extract on lead acetate Induced nephrotoxicity in albino wistar rats were investigated by analyzing various biochemical parameters. Lead acetate induced kidney damage was well manifested by significant increase in renal parameters like urea, uric acid creatinine and serum electrolytes sodium, potassium,chloride, calcium, phosphorous and TBARS and d...

  Objective(s): Because of the high total phenolic contents of Feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice.   Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP)...

Renal disorders have become very common nowadays, which may also lead to kidney failure. The disorder may be caused by the commonly used chemicals such as acetaminophen, CCl4, streptromycin, H2O2 etc. The objective of this work is to determine the nephroprotective potential of ethanolic extract against H2O2 induced toxicity in VERO cell line. Ethanolic extract is known for its antioxidant, anti...

OBJECTIVES To evaluate the effect of Graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. MATERIALS AND METHODS Animals were grouped into 6: Group 1 received gum acacia, Group 2 received G. pictum ethanol extract (300 mg/kg), Group 3 received gentamicin, Groups 4, 5, 6 received gentamicin along with G. pictum at ...

Cissampelos pareira Linn. (Menispermaceae) widely distributed all over India and it is widely used for various kidney disorders. According to the Ayurveda, the kidneys are made up of the "Rakta" and "Meda" dhatus. Treating these two dhatus is also an effective way to treat the kidneys. The plant Cissampelos pareira Linn. is used to treat these two dhatus. This promotes us to undertake a study t...

This study was conducted to quantitatively evaluate the antioxidant, antihemolytic and nephroprotective effects of Diospyros lotus seeds extract in experimental in vitro and in vivo models. Antioxidant potential of Diospvyos lotus seeds extract was examined by employing seven in vito models i.e., DPPH, nitric oxide and hydrogen peroxide radicals scavenging activity, iron ion chelating, reducing...

Medicinal plants may serve as a vital source of potentially useful new compounds for the development of effective therapy to combat a variety of kidney problems. Many herbs have been proven to be effectual as nephroprotective agents while many more are claimed to be nephroprotective but there is lack of any such scientific evidence to support such claims. Developing a satisfactory herbal therap...