We hypothesized that a chemically extracted acellular allogeneic nerve graft used in combination with bone marrow mesenchymal stem cell transplantation would be an effective treatment for long-segment sciatic nerve defects. To test this, we established rabbit models of 30 mm sciatic nerve defects, and treated them using either an autograft or a chemically decellularized allogeneic nerve graft w...

Diaphragmatic palsy due to intraoperative injury of the phrenic nerve leads severe ventilation disorders, a decrease in quality life, leveling effect main operation. According foreign authors, reconstruction is an optimal alternative diaphragm plication acute injuries nerve. This case describes first successful experience our country with intercostal graft patient locally advanced stage IIIB th...

BACKGROUND Despite substantial research into the topic and valiant surgical efforts, reconstruction of peripheral nerve injury remains a challenging surgery. This study was conducted to evaluate the effectiveness of axonal regeneration of a transected sciatic nerve through a vein conduit containing degenerated skeletal muscle compared with axonal regeneration in a transected sciatic nerve throu...

For patients diagnosed with advanced malignant parotid tumour, radical parotidectomy facial nerve sacrifice is part of the treatment. Multiple surgical techniques have been developed to cure paralysis in order restore function and aesthetics face. Despite large number publications over time on reanimation, a consensus timing procedure or donor graft selection has remained be established. Theref...

The hypothesis is that induced pluripotent stem cells (iPSC) derived Schwann cells and/or macrophages can be transplanted into acellular nerve graft in repairing injured nervous system. The efficiency of iPSC seeded acellular nerve graft may mimic the autologous peripheral nerve graft.

BACKGROUND There are many studies in the literature combining vein grafts with cell cultures, muscle, tendon, and nerve tissues, but none of them could replace isolated nerve grafts for nerve repair in clinical settings. There are studies in the literature indicating that adipose tissue derived stromal vascular fraction (SVF) enhances peripheral nerve healing. Considering these facts, an experi...

In this study, we investigated the feasibility of using autologous vein graft and platelet-derived growth factors to bridge transected cavernous nerve in a rat model. A short defect in the bilateral cavernous nerve was created and repaired with vein graft from the right jugular vein or vein graft plus platelet-derived growth factors. The 32 rats were divided into four groups, namely Group 1 - n...

BACKGROUND Peripheral nerve repair outcomes are suboptimal in the presence of severe soft tissue injury and excessive scarring paralleling the process in tendon reconstruction of the hand. Inspired by the advantages of the two-stage technique in tendon grafting and with encouraging preliminary results, we aimed to investigate the two-stage nerve grafting technique as an alternative method of se...

Introduction: Contralateral cervical 7 (CC7) nerve transfer can be used in the absence of neurotizer BPI total root avulsion case. CC7 was introduced by Gu et al. 1986, and aimed to restore motor sensory function hand. The purpose this paper is report patients with nearly using median nerve. Case Presentation: A man suffered a motorcycle accident March 2010. There complete loss right upper limb...