BACKGROUND Previous studies suggest a positive association between markers of trans-fatty acid intake and prostate cancer. We therefore prospectively evaluated the association between blood trans-fatty acid levels and risk of prostate cancer. METHODS We conducted a nested case-control study among 14,916 apparently healthy men who provided blood samples in 1982. Blood fatty acid levels were de...

BACKGROUND High consumption of trans fat has been linked to the risk of coronary heart disease (CHD). We assessed the hypothesis that higher trans fatty acid contents in erythrocytes were associated with an elevated risk of CHD in a nested case-control study among US women. METHODS AND RESULTS Blood samples were collected from 32,826 participants of the Nurses' Health Study from 1989 to 1990....

PURPOSE Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in a rat glioma model, and nested model selection (NMS), to compare estimates of the pharmacokinetic parameters vp , K(trans) , and ve for two different contrast agents (CAs)-gadofosveset, which reversibly binds to human serum albumin, and gadopentetate dimeglumine, which does not. MATERIALS AND METHODS DCE-MRI studi...

The effects of potassium ion on the nested allostery of GroEL are due to increases in the affinity for nucleotide. Both positive allosteric transitions, TT-TR and TR-RR, occur at lower [ATP] as [K(+)] is increased. Negative cooperativity in the double-ringed system is also due to an increase in the affinity of the trans ring for the product ADP as [K(+)] is increased. Consequently, (i) rates of...

Article history: Received 26 March 2014 Received in revised form 9 October 2014 Accepted 10 October 2014 Available online xxxx The sociotechnical systems (STS) approach provides a framework that is well suited to grappling with many issues of work in organizations. By conceiving of work systems as mutually-shaping social and technological systems, the STS approach has provided decades of resear...

We are concerned with the convergence of NEAR-DGD $$^+$$ (Nested Exact Alternating Recursion Distributed Gradient Descent) method introduced to solve distributed optimization problems. Under assumption strong convexity local objective functions and Lipschitz continuity their gradients, linear is established in Berahas et al. (IEEE Trans Autom Control 64:3141-3155, 2019). In this paper, we inves...

BACKGROUND Although trans fatty acids (TFAs) may increase the risk of dyslipidemia and coronary artery disease (CAD), limited data are available on their association with heart failure (HF). OBJECTIVE Our goal was to assess associations of plasma and dietary TFAs with HF and CAD. DESIGN We used a prospective, nested case-control design to select 788 incident HF cases and 788 matched control...

Title of Dissertation : ALLOSTERY AND GROEL: EXPLORING THE TENETS OF NESTED COOPERATIVITY Jennifer Suzanne Gresham, Doctor of Philosophy, 2004 Dissertation Directed By: Professor George H. Lorimer Department of Chemistry and Biochemistry Despite a wealth of structural and biochemical studies on the functional cycle of the E. coli chaperonins GroEL and GroES, no model proposed to date accounts f...

background :  q fever is a zoonotic disease caused by inhalation of the bacterium coxiella burnetii . ruminant livestock are common reservoirs for c. burnetii , and bacteria present in aerosols derived from the waste of infected animals can infect humans . c. burnetii is thought to infect humans primarily via airborne transmission. methods : 64 environmental swab samples were collected from 24 ...