نتایج جستجو برای: neural cell adhesion molecules

تعداد نتایج: 2098563  

Journal: :iranian biomedical journal 0
علی اکبر رجب زاده ali akbar rajabzadeh dept. of anatomical sciences and cellular biology, school of medicine, mashhad universityدانشگاه علوم پزشکی مشهد، دانشکده پزشکی، گروه علوم تشریحی و بیولوژی سلولی علیرضا ابراهیم زاده بیدسکان ali reza ebrahimzadeh bideskan dept. of anatomical sciences and cellular biology, school of medicine, mashhad universityدانشگاه علوم پزشکی مشهد، دانشکده پزشکی، گروه علوم تشریحی و بیولوژی سلولی حسین حقیر hossein haghir dept. of anatomical sciences and cellular biology, school of medicine, mashhad universityدانشگاه علوم پزشکی مشهد، دانشکده پزشکی، گروه علوم تشریحی و بیولوژی سلولی علیرضا فاضل ali reza fazel dept. of anatomical sciences and cellular biology, school of medicine, mashhad universityدانشگاه علوم پزشکی مشهد، دانشکده پزشکی، گروه علوم تشریحی و بیولوژی سلولی

background:the polysialylated neural cell adhesion molecule (psa-ncam) is expressed in developing brain. fetal brain damage is caused by different conditions such as seizure and hypoxia. the present study was designed to investigate the effect of maternal seizures on the number of psa-ncam positive cells in pup's hippocampus. methods: female wistar rats were divided into four groups: (a) k...

2012
Kousuke Shimada Toshiaki Tachibana Kei Fujimoto Takashi Sasaki Masataka Okabe

Recent studies have revealed that signals from neural crest (NC) derivatives regulate the mass, proliferation, and maturation of beta cells in developing fetal pancreas. However, little is known about the cellular distribution of NC derivatives during pancreatic development or the process whereby the developing islets are enclosed. We studied the temporal and spatial distribution of NC derivati...

2017
Maria Christina Sergaki Carlos F. Ibáñez

During embryonic development of the cerebellum, Purkinje cells (PCs) migrate away from the ventricular zone to form the PC plate. The mechanisms that regulate PC migration are incompletely understood. Here, we report that the neurotrophic receptor GFRα1 is transiently expressed in developing PCs and loss of GFRα1 delays PC migration. Neither GDNF nor RET, the canonical GFRα1 ligand and co-recep...

Journal: :The Journal of biological chemistry 2001
S Inoue Y Inoue

More precise information on the degree of polymerization (DP) of polysialic acid (polySia) chains expressed on neural cell adhesion molecule (NCAM) and its developmental stage-dependent variation are considered important in understanding the mechanism of regulated polysialylation and fine-tuning of NCAM-mediated cell adhesion by polySia. In this paper, first we performed a kinetic study of acid...

Journal: :Annual review of biochemistry 1997
C Chothia E Y Jones

Considerable advances have been made in our knowledge of the molecular structure of cell adhesion molecules, their binding sites, and adhesion complexes. For the cadherins, protein zero, and CD2, additional experimental data support the insights obtained from structural analysis of their domains and molecular models of their adhesion complexes. For neural cell adhesion molecules, L1, fibronecti...

2009
Meifang Xiao Melitta Schachner Konrad Wiese

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Journal: :The Journal of biological chemistry 2013
Matthew G Thompson Deirdre A Foley Karen J Colley

The neural cell adhesion molecule (NCAM) is the major substrate for the polysialyltransferases (polySTs), ST8SiaII/STX and ST8SiaIV/PST. The polysialylation of NCAM N-glycans decreases cell adhesion and alters signaling. Previous work demonstrated that the first fibronectin type III repeat (FN1) of NCAM is required for polyST recognition and the polysialylation of the N-glycans on the adjacent ...

Journal: :Hippocampus 2005
Shira Knafo Edi Barkai Ana I Herrero Frederic Libersat Carmen Sandi César Venero

The notion that long-term synaptic plasticity is generated by activity-induced molecular modifications is widely accepted. It is well established that neural cell adhesion molecule (NCAM) is one of the prominent modulators of synaptic plasticity. NCAM can be polysialylated (PSA-NCAM), a reaction that provides it with anti-adhesion properties. In this study we have focused on NCAM and on its pol...

Journal: :Brain research 2006
Bing Fang Liu Er Jing Gao Xian Zhi Zeng Man Ji Qing Cai Qiang Lu Hui Yang Qun Yuan Xu

The proliferative activity of neural precursors from the subventricular zone (SVZ) was investigated after a unilateral lesion was formed in the nigrostriatal pathway in adult rats. The lesion was formed by unilateral injection of 6-hydroxydopamine (6-OHDA) into the nigrostriatal pathway, and then bromodeoxyuridine (BrdU) was injected (ip) for 4 days or 2 weeks 10 days after the lesion was forme...

Most common hypotheses of seizure initiation are increased neural excitation, decreased inhibition or both. But, the conditions that lead to these activation states not to be clear yet. Recent studies challenge traditional concepts and indicate new evidence that a key epileptogenic process may actually begin in the blood vessel. Seizures could be initiate by a variety of insults to the brain, s...

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