protein aggregation is thought to be the pathological driving force responsible for neurodegenerative disorders such as alzheimer’s, parkinson’s, huntington’s, frontotemporal dementia, dementia with lewy bodies and prion diseases, however, it is not yet clear whether, or to what extent, the misfolded proteins are the cause of the diseases rather than the consequences. the aggregated proteins th...

neurodegeneration is a complex and multifaceted process leading to many chronic disease states. a conventional definition implies a progressive neuronal death, which usually affects a specific population of nerve cells the vulnerability of which determines the clinical manifestations of a particular neurodegenerative disease. the neurodegenerative process is associated with many events. each ev...

opDivision qf' Phauaacognosy, Department of' JdbdiclnaJ Resources, institute of Natural Medicine, Tbyama Medical and Pharmaceuticat University, 2630 Sugitani, Tbyama 930-OiP4, Jtu)an. bj21St Century COE Program, 7Q}'ama Mledical and Pharmaceuticat Uhivenylty, 2630 Sagitani, lb.Fama 930-OIV4, mpan. ofKampo Pharmaceutieal Sciences, Nihon Pharmaceutical University, 10281 Komuro, lna, Saitama 362-0...

Multiple Sclerosis (MS) is a complex disease resulting from the occurrence of intermingled episodes of neuroinflammation and degeneration. However, this concept has recently challenged by several observations suggesting that in this disease neurodegeneration might occur independently of inflammation. The evidence that active neurodegeneration in MS is invariably associated with inflammation is p...

Abstract: Aim: Lead is a powerful metal which induced neurotoxicity through the degradation of neurons in body. Various neuronal changes have shown correlation with generation free radicals and oxidative stress. The present study was carried out to evaluate neuroprotective activity Natrium diethyl dithiocarbamate trihydrate (NDDCT) on lead neurodegeneration rat’s model. Methods: We evaluated ND...

Chronic neurodegenerative diseases, such as prion diseases or Alzheimer's disease, are associated with progressive accumulation of host proteins which misfold and aggregate. Neurodegeneration is restricted to specific neuronal populations which show clear accumulation of misfolded proteins, whilst neighbouring neurons remain unaffected. Such data raise interesting questions about the vulnerabil...