Esophageal cancer incidence rates have been increasing over the past years and survival remain low. According to Global Cancer Observatory, 3.1% of new cases consists esophageal 5.5% deaths was due cancer. Histologic classification comprises either squamous cell carcinoma (SCC) or Adenocarcinoma. Other types are reported be uncommon. We present a case 33-year old male admitted progressive dysph...

Large cell neuroendocrine carcinoma (LCNEC) is a poorly differentiated that typically arises in the lung. Because of its rarity and poor prognosis, standardized treatment has not been established yet. A 53-year-old male was initially diagnosed as maxillary sinus squamous (SCC) arising from inverted papilloma (clinical stage T4bN2bM0, IVb), underwent concurrent chemoradiotherapy. After achieving...

Pulmonary neuroendocrine cells exhibit highly specialized differentiation with a neurosecretory phenotype and significant bioactive peptide hormone content. In addition to these functions, pulmonary neuroendocrine cells have been demonstrated to act as chemoreceptors for hypoxia (1). Specific pulmonary disorders, including bronchopulmonary dysplasia, bronchiectasis, cystic fibrosis, pulmonary h...

BACKGROUND Mixed (composite) exocrine-neuroendocrine cell carcinomas are defined as an intimate admixture of neoplastic glandular exocrine and neuroendocrine cell types. Although gastric adenocarcinoma containing a small number of neuroendocrine cells is a relatively frequent occurrence, gastric neoplasms containing equal proportions of both cell types are rare. CASE PRESENTATION We present a...

metastasis from a malignant tumor to the palatine tonsils is rare, accounting for only 0.8% of all tonsillar tumors, with only 100 cases reported in the english-language literature. various malignant lung carcinomas may metastasize to the tonsils. a few cases of tonsillar metastasis from neuroendocrine lung carcinoma have been reported. a 67-year-old female underwent a right tonsillectomy becau...

1. Incipient neuroendocrine neoplasia: Dysplasia/Tis 2. True neuroendocrine tumors a. Well differentiated NETs (carcinoids, pancreatic neuroendocrine neoplasms) b. High-grade neuorendocrine carcinoma 3. Hybrid tumors a. Mixed tumors i. Mixed adenocarcinoma-neuorendocrine carcinoma ii. Mixed neuorendocrine tumor and non-neuroendocrine carcinoma iii. Duodenal gangliocytic paraganglioma b. Inciden...

CONTEXT Lung and breast carcinomas are among the most prevalent cancers. Advances in cancer therapies can provide survival benefit and be potentially curative, even in metastatic disease. Due to the high prevalence of these carcinomas, it is not unusual to encounter lung nodule(s) in a patient with breast carcinoma, and distinguishing between primary and metastatic disease is critical for manag...

YAP1, the main Hippo pathway effector, is a potent oncogene and is overexpressed in non-small-cell lung cancer (NSCLC); however, the YAP1 expression pattern in small-cell lung cancer (SCLC) has not yet been elucidated in detail. We report that the loss of YAP1 is a special feature of high-grade neuroendocrine lung tumors. A hierarchical cluster analysis of 15 high-grade neuroendocrine tumor cel...

Objectives CD200 expression has been well studied in hematopoietic malignancies; however, CD200 expression has not been well-characterized in neuroendocrine neoplasms. We examined CD200 expression in 391 neuroendocrine neoplasms from various anatomic sites. Methods Tissue blocks containing pulmonary small cell carcinoma, pulmonary carcinoid, large cell neuroendocrine carcinoma, pancreatic neu...

endocrine tumors of the pancreas (islet-cell tumors) are rare with neuroendocrine origin. the patient was a 41- year- old man, admitted with chief complains of epigastric mass feeling, dull abdominal pain, lack of appetite and weight loss up to 2-3 kg since 6 months ago. in physical examination, a mass was detected in epigaster and left upper quadrant (luq). in abdominal x-ray, a calcified mass...