نتایج جستجو برای: neuromuscular junction
تعداد نتایج: 68614 فیلتر نتایج به سال:
The neuromuscular junction is the chemical synapse between motor neurons and skeletal muscle fibers. It is designed to reliably convert the action potential from the presynaptic motor neuron into the contraction of the postsynaptic muscle fiber. Diseases that affect the neuromuscular junction may cause failure of this conversion and result in loss of ambulation and respiration. The loss of moto...
BACKGROUND AND OBJECTIVE Congenital myasthenic syndromes are rare inherited disorders characterized by fatigable weakness caused by malfunction of the neuromuscular junction. We performed whole exome sequencing to unravel the genetic aetiology in an English sib pair with clinical features suggestive of congenital myasthenia. METHODS We used homozygosity mapping and whole exome sequencing to i...
background: prolonged inhibition of acetylcholine esterase may lead to the intermediate syndrome. neuromuscular junction (nmj) dysfunction has been shown with repetitive nerve stimulation (rns). subclinical nmj dysfunction may also occur. we aimed to examine the nmj function following acute organophosphorus (op) poisoning by using exercise modified slow rns. methods: a cohort study was conducte...
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In spite of the available information about the development of Drosophila neuromuscular junctions, the correlation between nerve terminal morphology and maintenance of synaptic strength has still not been systematically addressed throughout larval development. We characterized the growth of the abdominal longitudinal muscle 6 (m6) and the motor terminals Ib and Is that innervate it within segme...
The neuromuscular junctions are the specialized synapses whereby spinal motor neurons control the contraction of skeletal muscles. The formation of the neuromuscular junctions is controlled by a complex interplay of multiple mechanisms coordinately activated in motor nerve terminals and in their target myotubes. However, the transcriptional regulators that control in motor neurons the genetic p...
TH. 2017 Correction to 'NMJ-morph reveals principal components of synaptic morphology influencing structure– function relationships at the neuromuscular junction'.
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The molecular mechanisms that regulate the organization and activity of the neuromuscular junction remain to be fully identified. Caveolae are invaginations of the plasma membrane. Caveolin-3 is the structural protein component of caveolae in muscle cells. We show that caveolin-3 is expressed at the neuromuscular junction, that it associates with the nicotinic acetylcholine receptor (nAChR), an...
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