نتایج جستجو برای: neuropathic itch
تعداد نتایج: 14850 فیلتر نتایج به سال:
Itch can be suppressed by painful stimuli, but the underlying neural basis is unknown. We generated conditional null mice in which vesicular glutamate transporter type 2 (VGLUT2)-dependent synaptic glutamate release from mainly Nav1.8-expressing nociceptors was abolished. These mice showed deficits in pain behaviors, including mechanical pain, heat pain, capsaicin-evoked pain, inflammatory pain...
The specific pathway of "pure," histaminergic itch is traced from the mechano-insensitive nerve fibers in the skin to their central cortical projections. Neuropathic itch created at different levels of this anatomical pathway is reviewed. In this review the present author discusses damage to pruritoceptors in the skin, entrapment syndromes, damage to spinal ganglia, nerve root impingement, inju...
Voltage-gated sodium (NaV) channels control the upstroke of the action potentials in excitable cells. Multiple studies have shown distinct roles of NaV channel subtypes in human physiology and diseases, but subtype-specific therapeutics are lacking and the current efforts have been limited to small molecules. Here, we present a monoclonal antibody that targets the voltage-sensor paddle of NaV1....
The 4th International Workshop for the Study of Itch* was held 9–11 September 2007 in San Francisco, California. For the first time, the meeting was sponsored in part by a grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the Office of Rare Diseases of the National Institutes of Health. Also for the first time, the meeting was held under the auspices of th...
The gate control theory of pain proposes that inhibitory neurons of the spinal dorsal horn exert critical control over the relay of nociceptive signals to higher brain areas. Here we investigated how the glycinergic subpopulation of these neurons contributes to modality-specific pain and itch processing. We generated a GlyT2::Cre transgenic mouse line suitable for virus-mediated retrograde trac...
P atients with brachioradial pruritus (BRP) often report that their itch feels ‘‘deep,’’ that scratching only makes it worse, and that the only thing that provides any relief is the application of ice packs, chilling the skin to the point of numbness. The ice-pack sign is nearly pathognomonic for this condition. The weight of available evidence suggests that BRP is a neurogenic/neuropathic itch...
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