background and aims: neurons are injured under physical, chemical and pathological conditions. the effect of peripheral nervous system injuries may return as retrograde to the cell body of neurons in central nervous system resulting in brain and spinal cord degeneration. because of high content of camphor and borneol, achillea biebersteinii from asteracea family may be effective in prevention t...

objective(s) the brief interruption of cerebral blood flow causes permanent brain damage and behavioral dysfunction. the hippocampus is highly vulnerable to ischemic insults, particularly the ca1 pyramidal cell layer. there is no effective pharmacological strategy for improving brain tissue damage induced by cerebral ischemia. previous studies reported that pentoxifylline (ptx) has a neuroprote...

introduction: preliminary studies have con.rmed reduction in cell death following treatment with antioxidants. according to this .nding we study the relationship between consumption of coq10 and expression of bax and bcl2 in hippocampus following ischemia/reperfusion as proteins involved in cell programmed death or apoptosis. methods: we studied the protective role of coq10 against ischemia-rep...

introduction: the inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (cox). cox catalyzes the formation of prostaglandins from arachidonic acid. among prostaglandins, 15-deoxy-d12, 14-prostaglandin j2 (15d-pgj2), an endogenous ligand of peroxisome proliferator-activated receptor-gamma (ppar-γ), has been demonstrated to have anti-inflam...

background and objectives: oxidative stress is implicated in the neuronal damage associated with alzheimer’s disease, parkinson’s disease, huntington’s disease, amyotropic lateral sclerosis and cerebral ischemic stroke. the present work was designed to establish the neuroprotective effects of salvia aristata extract on h2o2-induced apoptosis in human dopaminergic sh-sy5y cells. methods: the tot...

objective: to determine the effects of recombinant human erythropoietin (rhepo) on functional outcome and disability of patients with traumatic cervical spinal cord injury (sci).  methods: this was a randomized, double blind, placebo controlled clinical trial being performed in nemazee and shahid rajaei hospitals of shiraz during a 3-year period from 2011 to 2014. a total number of 20 patients ...

objective(s): erythropoietin (epo), is a 34kda glycoprotein hormone, which belongs to type 1 cytokine superfamily. epo involves in erythrocyte maturation through inhibition of apoptosis in erythroid cells. besides its main function, protective effects of epo in heart and brain tissues have been reported. epo has a critical role in development, growth, and homeostasis of brain. furthermore epo h...

Stroke is a devastating medical condition, killing millions of people each year and causing serious injury to many more. Despite advances in treatment, there is still little that can be done to prevent stroke-related brain damage. The concept of neuroprotection is a source of considerable interest in the search for novel therapies that have the potential to preserve brain tissue and improve ove...