Section 1.11 discusses basic molecular neurobiology, section 1.12 Please verify cross references. discusses psychoneuroendocrinology, and neuropsychiatric aspects of endocrine disorders are discussed in section 24.7. The cross references provided above seemed to be out of date and have been updated to correspond to the table of contents of the most recent edition. Please verify that the update ...

Nervous system lesions are characterized by the loss of neuronal numbers and types. The neurotrophic factor levels in an injured tissue reflect their potential for regeneration. This hypothesis was investigated in olfactory bulb (OB), where olfactory tract was surgically transected disrupting neuronal migration and turnover. The effects were followed with quantification of mitral cells and thre...

Background Brain-derived neurotrophic factors are known to be related to the psychopathology of major depressive disorder. However, studies focusing on drug-naïve first-episode patients are still rare. Methods Over a 6-year period, we examined the serum brain-derived neurotrophic factors levels in patients with first-episode drug-naïve major depressive disorder and compared them with sex-match...

Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer's disease and Parkinson's disease show changes in the ...

Neurotrophic factors are playing vital roles in survival, growth, and function of neurons. Regulation of neurotrophic factors in the brain has been considered as one of the targets in developing drug or therapy against neuronal disorders. Flavonoids, a family of multifunctional natural compounds, are well known for their neuronal beneficial effects. Here, the effects of flavonoids on regulating...

Adipose-derived stem cells are a kind of mesenchymal stem cells which have a higher frequency in the adipose tissue and can be harvested by minimally invasive procedures. These cells are able to differentiate into other cells outside their lineage such as neuron, neurotrophic factor secreting cells and Schwann cells. Many of the identified neurotrophic factors such as brain-derived neurotrophic...

Local delivery of neurotrophic factors is a pillar of neural repair strategies in the peripheral nervous system. The main disadvantage of the free growth factors is their short half-life of few minutes. In order to prolong their activity, we have conjugated to iron oxide nanoparticles three neurotrophic factors: nerve growth factor (βNGF), glial cell-derived neurotrophic factor (GDNF), and basi...