BACKGROUND Serious adverse drug reactions of disease-modifying drugs in multiple sclerosis (MS) therapy may include enhanced susceptibility to reactivation of neurotropic herpes viruses like varicella-zoster virus (VZV) and the John Cunningham (JC) polyomavirus. OBJECTIVE Because symptomatic reactivation of these viruses are rare events, we determined the incidence of rises in anti-VZV IgG an...

The amplified fragment length polymorphism technique has been applied to identify neurotropic chaetothyrialean black yeasts and relatives from clinical sources. Cladophialophora bantiana, C. emmonsii, C. arxii, C. devriesii, and C. modesta, previously identified on the basis of sequencing and phenotypic and physiological criteria, were confirmed by cluster analysis, demonstrating the clear sepa...

The review presents the results of studies on pharmacokinetics, metabolism, and bioavailability new neurotropic dipeptide cyclo-Lprolilglycine (CPG) their pharmacological activity. It was shown that pharmacologically active metabolite nootropic drug noopept is an endogenous dipeptide, it a fragment terminal Tripeptide insulin-like nerve growth factor IGF-1. Much attention paid both in Russia ab...

It is well known that some strains of the influenza virus are rendered to be neurotropic, and this expression means that these neurotropic strains cause death to mice with cerebral symptomes and multiply in the brain if inoculated intracerebrally. The histopathological changes in mice infected with a neurotropic variant of influenza virus were described by Stuart-Harris(1), according to whom th...

Abstract Picornaviridae are a family of small positive-strand RNA viruses, and transmitted via the respiratory or fecal-oral route. The neurotropic picornaviruses can induce acute late recurrent seizures following central nervous system infection, by infecting peripheral nerve, crossing blood-brain barrier migrating in Trojan-horse method. Theiler’s murine encephalomyelitis virus (TMEV), as mem...

West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide.  Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae.  Neither antiviral drugs nor vaccines are available for humans.  Animal models have been used to investigate WNV pathogenesis and host immune response in...

Although neurological manifestations associated with dengue viruses (DENV) infection have been reported, there is very limited information on the genetic characteristics of neurotropic DENV. Here we describe the isolation and complete genome analysis of DENV serotype 3 (DENV-3) from cerebrospinal fluid of an encephalitis paediatric patient in Jakarta, Indonesia. Next-generation sequencing was e...