Nitric oxide (NO) derived from inducible NO synthase (iNOS) contributes to the pathophysiology of acute lung injury (ALI). The effect of iNOS on pulmonary neutrophil infiltration in ALI is not known. Thus, we assessed pulmonary microvascular neutrophil sequestration through intravital videomicroscopy and pulmonary neutrophil infiltration, reflected by myeloperoxidase activity and lavage neutrop...

Frink M, Thobe BM, Hsieh Y-C, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH. 17 -Estradiol inhibits keratinocytederived chemokine production following trauma-hemorrhage. Am J Physiol Lung Cell Mol Physiol 292: L585–L591, 2007. First published November 3, 2006; doi:10.1152/ajplung.00364.2006.—Neutrophil infiltration is a key step in the development of organ dysfunction following trauma-hemorrha...

Background: The pathological features of severe cardiac injury induced by COVID-19 and relevant clinical is unknown. Methods: This autopsy cohort study, including hearts from 26 deceased patients hospitalized in intensive care unit due to COVID-19, was conducted at four sites Wuhan, China. Cases were divided into neutrophil-infiltration group no-neutrophil according histopathological identif...

Excessive neutrophil infiltration in vital organs is life-threatening to patients who suffer from sepsis. We identified a critical role of exogenous carbon monoxide (CO) in the inhibition of neutrophil infiltration during lipopolysaccharide (LPS)-induced sepsis. CO delivered from carbon monoxide-releasing molecule 2 (CORM-2) dramatically increased the survival rate of C57BL/6 mice subjected to ...

Meldrum, Kirstan K., Daniel R. Meldrum, Xianzhong Meng, Lihua Ao, and Alden H. Harken. TNF-dependent bilateral renal injury is induced by unilateral renal ischemiareperfusion. Am J Physiol Heart Circ Physiol 282: H540–H546, 2002; 10.1152/ajpheart.00072.2001.—While tumor necrosis factor (TNF)is an important mediator of renal ischemiareperfusion (I/R) injury, its role in contralateral renal injur...

Neutrophil adhesion and migration are critical in hepatic ischemia/reperfusion (I/R) injury. Despite very strong preclinical data, recent clinical trials failed to show a protective effect of anti-adhesion therapy in reperfusion injury. Therefore, the aim of this study was to assess the role of CD44 in neutrophil infiltration and liver injury from hepatic I/R. In this study, using a partial hep...

Fas ligand (FasL) has been well characterized as a death factor. However, recent studies revealed that ectopic expression of FasL induces inflammation associated with massive neutrophil infiltration. We previously demonstrated that the neutrophil infiltration-inducing activity of FasL is partly dependent on, but partly independent of, IL-1beta. Here we investigated the cytokine profile of perit...

It is generally believed that the clearance of apoptotic cells does not lead to inflammation. In contrast, we previously found that injection of apoptotic cells into the peritoneal cavity induced the expression of an inflammatory chemokine, MIP-2, and infiltration of neutrophils, and that anti-MIP-2 Abs suppressed the infiltration significantly. Because our previous study showed that whole-body...

Despite the lack of a proinflammatory response to LPS, CD14-deficient mice clear Gram-negative bacteria (Escherichia coli 0111) at least 10 times more efficiently than normal mice. In this study, we show that this is due to an early and intense recruitment of neutrophils following the injection of Gram-negative bacteria or LPS in CD14-deficient mice; in contrast, neutrophil infiltration is dela...