Ibe, Basil O., Fred C. Sander, and J. Usha Raj. Platelet-activating factor receptors in lamb lungs are downregulated immediately after birth. Am J Physiol Heart Circ Physiol 278: H1168–H1176, 2000.—Platelet-activating factor (PAF) is a phospholipid with diverse biological functions mediated by a G protein-coupled receptor. We determined PAF receptor binding in lung membranes of four groups of p...

BACKGROUND Using esophageal pHmetry, nasal CPAP (nCPAP) has been shown to decrease acid gastroesophageal reflux (GER) in adult humans. Although both GER (mainly non-acid) and nCPAP use are very frequent in newborns, the effect of nCPAP on GER in early life is unknown. Having recently shown that the newborn lamb is a unique model for studying neonatal GER, our main objective was to assess the ef...

Ewes were injected intramuscularly with 1 ml iodised oil at mating or during the first two months of pregnancy to determine if marginal iodine deficiency contributed to the high mortality of newborn lambs in Victoria. Iodine treatment markedly increased milk iodine concentration of ewes. In nine of ten trials conducted in 1979 and 1980 at Ararat, Hamilton, Langi Kal Kal, Ruffy, Rutherglen and T...

In this paper, a mathematical model of the respiratory mechanics is used to reproduce experimental signal waveforms acquired from three newborn lambs. As the main challenge is to determine specific lamb parameters, a sensitivity analysis has been realized to find the most influent parameters, which are identified using an evolutionary algorithm. Results show a close match between experimental a...