نتایج جستجو برای: ngal

تعداد نتایج: 1353  

2017
Kyoko Yoshikawa Motoh Iwasa Akiko Eguchi Shinichi Kojima Naohiko Yoshizawa Mina Tempaku Ryosuke Sugimoto Norihiko Yamamoto Kazushi Sugimoto Yoshinao Kobayashi Hiroshi Hasegawa Yoshiyuki Takei

Chronic liver disease patients often have complications, such as hepatocellular carcinoma (HCC) and acute bacterial infection. Model for end-stage liver disease and Child-Pugh scores are useful prognostic factors for chronic liver diseases but not for all chronic conditions, such as HCC. Our investigative aim targeted the prognostic abilities of neutrophil gelatinase-associated lipocalin (NGAL)...

2012
Ying Chu Lee Woan-Fang Tzeng Tzeon-Jye Chiou Sin Tak Chu

The expression of neutrophil gelatinase-associated lipocalin (NGAL) is up-regulated in some cancers; therefore NGAL has potential as a tumor biomarker. Although the regulation mechanism for this is unknown, one study has shown that it is likely to involve a microRNA (miRNA). Here, we investigate the relation between miRNA expression and NGAL expression, and the role of NGAL in tumorigenesis. Us...

2012
Kwang-Sook Woo Jae-Lim Choi Bo-Ram Kim Ji-Eun Kim Won-Suk An Jin-Yeong Han

BACKGROUND Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker of acute kidney injury. There is a growing body of evidence suggesting that NGAL is also a marker of kidney disease and severity in chronic kidney disease (CKD). We studied the utility of urinary NGAL in more accurately predicting renal function in patients with diabetic CKD. METHODS We studied possible rela...

2012
William H. Chappell Stephen L. Abrams Giuseppe Montalto Melchiorre Cervello Alberto M. Martelli Saverio Candido Massimo Libra Jerry Polesel Renato Talamini Ralph Arlinghaus Linda S. Steelman James A. McCubrey

Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron. NGAL also has important biological functions involved in immunity and inflammation as well as responses to kidney damage. NGAL expression ...

Journal: :Cardiovascular research 2011
Bernard C te Boekhorst Sandra M Bovens Willem E Hellings Petra H van der Kraak Kees W van de Kolk Aryan Vink Frans L Moll Matthijs F van Oosterhout Jean P de Vries Pieter A Doevendans Marie-José Goumans Dominique P de Kleijn Cees J van Echteld Gerard Pasterkamp Joost P Sluijter

AIMS Neutrophil gelatinase-associated lipocalin (NGAL) is an effector molecule of the innate immune system. One of its actions is the prolongation of matrix metalloproteinase-9 (MMP-9) activity by the formation of a degradation-resistant NGAL/MMP-9 complex. We studied NGAL in human atherosclerotic lesions and we examined whether NGAL could act as a target for molecular imaging of atheroscleroti...

Journal: :Journal of clinical pathology 2011
Ze-Peng Du Zhuo Lv Bing-Li Wu Zhi-Yong Wu Jin-Hui Shen Jian-Yi Wu Xiu-E Xu Qiao Huang Jian Shen Hai-bin Chen En-Min Li Li-Yan Xu

AIM Previous studies have shown that neutrophil gelatinase-associated lipocalin (NGAL) is overexpressed in oesophageal squamous cell carcinoma (ESCC) and closely associated with the invasiveness of ESCC cells. Recently, NGAL receptor (NGALR) was identified from ESCC cells, and was also found to be increased in ESCC. The purpose of this study was to reveal the clinical significance of NGAL and/o...

Journal: :journal of comprehensive pediatrics 0
nastaran khosravi pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iran hosein karimi pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) nasrin khalesi pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) rozita hoseini pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) mitra mehrazma pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) niloofar khosravi ali-asghar children hospital, iran university of medical sciences, tehran, ir iran; ali-asghar children hospital, iran university of medical sciences, tehran, ir iran. tel: +98-2144297768سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)

conclusions sepsis enhances the production of plasma ngal in critically ill neonates. thus plasma ngal can help clinicians diagnose sepsis in critically ill neonates during early phases. results the ngal levels were significantly higher in septic neonates compared with non-septic neonates (102.9 ± 69.9 ng/ml versus 29.2 ± 13.3 ng/ml, p value = 0.0001). an optimal cut off-point of 48 ng/ml for s...

2014
Sandrine Bouchet Brigitte Bauvois

Matrix metalloproteinase (MMP)-9 and neutrophil gelatinase-associated lipocalin (NGAL) have gained attention as cancer biomarkers. The inactive zymogen form of MMP-9 (pro-MMP-9) also exists as a disulphide-linked heterodimer bound to NGAL in humans. Leukaemias represent a heterogeneous group of neoplasms, which vary in their clinical behavior and pathophysiology. In this review, we summarize th...

Ali Rahimipour, Esmat Ghanei, Faranak Kazerouni, Fatemeh Gharishvandi, Malihe Nasiri,

Background: Hypertension is one the most common causes of chronic kidney disease (CKD). One of the major concerns in hypertensive patients is early detection of renal disorders. In the past, serum creatinine (Scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated lipocal...

Journal: :Cancer research 2008
Zhimin Tong Ajaikumar B Kunnumakkara Huamin Wang Yoichi Matsuo Parmeswaran Diagaradjane Kuzhuvelil B Harikumar Vijaya Ramachandran Bokyung Sung Arup Chakraborty Robert S Bresalier Craig Logsdon Bharat B Aggarwal Sunil Krishnan Sushovan Guha

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa secreted acute phase protein, which is also up-regulated in multiple cancers, including breast, lung, and pancreas. Recently, NGAL has been proposed as an early biomarker in pancreatic cancer (PaCa). However, its biological role in PaCa is unknown. In this study, we examined in vitro and in vivo the functional role of NGAL in PaCa. W...

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