Mesoporous bioactive nanoparticles (MBNs) have been developed as promising additives to various types of bone or dentin regenerative material. However, biofunctionality of MBNs as dentin regenerative additive to dental materials have rarely been studied. We investigated the uptake efficiency of MBNs-NH2 with their endocytosis pathway and the role of MBNs-NH2 in odontogenic differentiation to cl...

BACKGROUND Head and neck squamous cell carcinoma (HNSCC) is currently the eighth leading cause of cancer death worldwide. The often severe side effects, functional impairments and unfavorable cosmetic outcome of conventional therapies for HNSCC have prompted the quest for novel treatment strategies, including the evaluation of nanotechnology to improve e.g. drug delivery and cancer imaging. Alt...

A hybrid composite based on metal-organic framework (MOF) was chemically fabricated by embedding the magnetic Fe3O4 nanoparticles within amino-functionalized porous La-MOF (MOF/NH2) to produce a highly efficient and reusable of MOF/NH2/Fe3O4. Different proper techniques were used for characterization surface morphology chemical arrangement prepared MOF/NH2/Fe3O4 composite. The results using var...

In the research field of nanoparticles, many studies demonstrated a high impact of the shape, size and surface charge, which is determined by the functionalization, of nanoparticles on cell viability and internalization into cells. This work focused on the comparison of three different nanoparticle types to give a better insight into general rules determining the biocompatibility of gold, Janus...

We report on preparing assemblies of gold nanoparticles with continuous gradients in number density on flat silica-covered substrates. The methodology consists of (i) first forming a one-dimensional molecular gradient of amino groups (-NH2) on the substrate by vapor deposition of amine-terminated silane molecules, followed by (ii) attachment of gold nanoparticles to -NH2 functional groups by im...

Nanoparticles with widely varying physical properties and origins (spherical versus irregular, synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus large) have been previously noted to translocate across the cell plasma membrane. We have employed atomic force microscopy to determine if the physical disruption of lipid membranes, formation of holes and/or th...

Catalytic aerobic oxidation of benzyl alcohol (BnOH) to benzaldehyde (PhCHO) over supported noble metal catalysts has grabbed the attention researchers due critical role PhCHO in numerous industrial syntheses. In present study, a novel catalyst, Pd-P alloy on aminopropyl-functionalized mesoporous silica (NH2-SiO2), was prepared through situ reduction and characterized by BET-BJH analysis, SEM, ...

Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. The early and effective diagnosis has always been desired. Herein, we present the preparation and characterization of hyaluronic acid (HA)-modified, multifunctional nanoparticles (NPs) targeting CD44 receptor-expressing cancer cells for computed tomography (CT)/magnetic resonance (MR) dual-mode imaging. We first mod...

in this paper, covalent immobilization of beta amylase enzyme on the surface of modified magnetic nano particles (znfe2o4@sio2-nh2) is reported. for doing so, at first, the magnetic nanoparticles of znfe2o4 were synthesized by chemical co-precipitation method and then tetraethyl orthosilicate (teos) and 3-aminopropyltriethoxy silane (aptes) were used for modification of znfe2o4 nanoparticles wi...

In this study, we analyzed the antimicrobial activities of poly-N-isopropylacrylamide (pNIPAM)-based polymeric nanoparticles encapsulating silver nanoparticles (AgNPs). Three sizes of AgNP-encapsulating pNIPAM- and pNIPAM-NH2-based polymeric nanoparticles were fabricated. Highly stable and uniformly distributed AgNPs were encapsulated within polymeric nanoparticles via in situ reduction of AgNO...