Autoimmune hemolytic anemia (AIHA) is characterized by shortened red cell survival due to the presence of autoantibodies directed against antigens on the red blood cell membrane. Corticosteroids and rarely intravenous immunoglobulin G are used in the treatment of AIHA. We report a six-month-old boy with severe AIHA who initially responded to high dose methylprednisolone (HDMP) and intravenous i...

​A anemia hemolítica autoimune (AIHA) é uma doença incomum, em que ocorre a destruição de hemácias mediada por autoanticorpos do hospedeiro, sendo sua patogênese ainda pouco esclarecida. O presente estudo descreve um caso mulher 45 anos com idiopática clínica sugestiva mediação anticorpos quentes (w-AIHA) e laboratório confirmatório aglutinina fria (DAC). Observou-se história comum às anemias h...

Autoimmune cytopenias occur in up to 10% of patients during the course of chronic lymphocytic leukemia (CLL), with autoimmune hemolytic anemia (AIHA) the most common, followed by immune-mediated thrombocytopenia (ITP). These disorders may occur at any time during disease course and depend on complex interactions between the malignant clone, impaired T-cell function, microenvironment and the imm...

The ovarian cystic teratoma is a rare cause of autoimmune haemolytic anaemia by warm antibodies, resistant to corticotherapy, with few case reports published in the medical literature. We present a case of a 45-year-old woman admitted to hospital due to general weakness. Laboratory studies revealed macrocytic anaemia, biochemical parameters of haemolysis and peripheral spherocytosis. The direct...

BACKGROUND There has been no report on the clinical features or natural history of autoimmune hemolytic anemia (AIHA) in the Korean adult population. This study retrospectively analyzed the clinical characteristics and long-term outcomes of AIHA in the Korean adults. METHODS Patients newly diagnosed with AIHA between January 1994 and December 2010 at Chungnam National University Hospital were...

Autoimmune hemolytic anemia (AIHA) is a relatively rare disorder with an incidence of 1-3 per 100,000 [1]. Warm AIHA (WAIHA) is typically due to IgG autoantibodies with optimal reactivity at 37°C and account for the vast majority of AIHA cases (80-90%) [1,2]. Clinical presentation can range from an asymptomatic, compensated hemolytic anemia to acute life-threatening hemolysis. Hemolysis is typi...

BACKGROUND The therapeutic efficacy of red blood cell (RBC) transfusions in patients with autoimmune hemolytic anemia (AIHA) is highly debated because of speculations on the increased risk of transfusion reactions; yet it is a suggested adjuvant therapy in anemic patients with life-threatening hypoxemia. In this study, we evaluated the safety and efficacy of RBC transfusions in AIHA patients. ...

OBJECTIVES Intraperitoneal (IP) injection of 3.5 g/kg L-arginine (known to induce acute pancreatitis) in rats will result in much greater increases in serum ornithine versus citrulline concentration (Crit Care Med. 2008;36:2117-2127). These data indicate a major role of arginase in the catabolism of L-arginine. Therefore, we tested the effects of the irreversible arginase inhibitor (+)-S-2-amin...

in order to evaluate the efficacy of some new herbicides in corn farms, a field study was conducted during the 2010 growing season in jiroft. the experimental design was completely randomized blocks, with 11 treatments and 4 replications. treatments were nicosulfuron at 2lit/ha, foramsulfuron at 2.5 lit/ha, rimsulfuron at 50 g/ha, nicosulfuron+ rimsulfuron at 175 g/ha, bromoxynil+mcpa at 1.5 li...

Transgene spreading is a major concern in cultivating genetically modified (GM) corn. Cross-pollination may cause the spread of transgenes from GM cornfields to conventional fields. Occasionally, seed lot contamination, volunteers, mixing during sowing, harvest, and trade can also lead to transgene escape. Obviously, new biological confinement technologies are highly desired to mitigate transge...