Objectives: The purpose of this research work was to formulate and systemically evaluate in vitro performances polymeric microspheres nifedipine. Methods: Nifedipine containing two polymers, poloxamer 407 carbopol 934, were prepared by single emulsion cross-linking technique. Glutaraldehyde selected as the agent. A Box–Behnken design employed study effect independent variables, polymer concentr...

To compare pregnancy latency achieved with oral labetalol versus extended-release nifedipine during expectant management of preterm preeclampsia severe features (PEC-SF). This is a retrospective cohort study patients initiated on antihypertensive therapy or admission for PEC-SF < 34 weeks between 1/2013 and 4/2022. Those prior to another indication delivery were excluded (monochorionic-monoamni...

Background: Preterm labor remains one of the major cause neonatal morbidity and mortality. Different tocolytics have been studied for prolongation pregnancy, role progesterone in increasing latency period controversial. Aim study was to compare efficacy nifedipine with along dydrogesterone as a tocolytic agent case preterm find its impact on maternal outcome. Methods: This conducted 100 women w...

there is strong evidence demonstrating that nifedipine dissolved in ethanol selectively inhibits only l-type ca2+ current. in addition, acute ethanol exposure reduces voltage-dependent calcium currents. in the present study, we investigated the antagonistic effect of fixed concentration of nifedipine dissolved in different concentration of ethanol on l-type ca2+ current. in a na+-k+ free soluti...

Objectives In order to provide a pharmacological profile for some newly synthesized dihydropyridines, we investigated their effects on the isolated rat colon segments and the isolated rat atrium contractility. The tested compounds include alkyl ester analogues of nifedipine, in which the ortho-nitrophenyl group at position 4 is replaced by 2-alkylthio-1-benzyl-5-imidazolyl substituent, and nif...

Nifedipine (NIF), a 1,4-dihydropyridine calcium channel antagonist, undergoes photo-degradation to dehydro-nifedipine (DNIF) upon exposure to ultraviolet (UV) light and to the nitroso analogue of dehydro-nifedipine (NDNIF) when exposed to sunlight or some kinds of artificial lights. NIF photo-degradation products do not contribute to clinical activity, thus prevention of photo-degradation of NI...

Objective(s) This study aimed to investigate and to compare the effects of nifedipine and amlodipine, dihydropyridine (DHP) calcium channel blockers (CCBs) on perfusion pressure of isolated perfused rat kidney. Materials and Methods Following the establishment of renal perfusion with a constant baseline pressure of 85-95 mmHg, the renal vasculature was constricted by phenylephrine (PE) injec...

OBJECTIVES The purpose of this study was to assess the utility of inhaled nitric oxide (NO), a selective pulmonary vasodilator, for predicting the safety and acute hemodynamic response to high-dose oral nifedipine in primary pulmonary hypertension (PPH). BACKGROUND A significant decrease in pulmonary vascular resistance with an oral nifedipine challenge is predictive of an improved prognosis,...

-Our objective was to compare cardiovascular event rates in patients with stable angina receiving nifedipine as monotherapy or combination therapy and in active drug controls. A MEDLARS search of published articles from 1966 to 1995 in English, French, German, Italian, or Spanish, supplemented by a manual search of bibliographies, identified 60 randomized controlled trials that met protocol cri...