AND PREDICTION OF DNA DAMAGE B.R.Prajapati *, A.K.Seth, K.I.Molvi, I.S.Rathod, B.N.Suhagia, M.M.Mansuri, D.G.Desai 1,4 & 5 L.M.College of Pharmacy, Navrangpura, Ahmedabad-09, Gujarat-India. 2 Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya,Gujarat-India. 3 Ali-Allana College of Pharmacy, Department of Pharmaceutical Medicinal Chemistry, Akkalkuawa, Nandurbar, 425415 – India. 6,7 P&M Kans...

Four different nitroimidazole derivatives, with up to two iodine atoms on the imidazole ring, were investigated for their radiosensitizing potency under hypoxic conditions, in order to test whether the introduction of iodine atoms increases the radiosensitizing potency of nitroimidazoles. Misonidazole and metronidazole were used as controls. Human colonic adenocarcinoma cells were incubated wit...

Nitroimidazoles are pharmacophoric groups responsible for important antiparasitic activity against several infectious diseases. 2-Nitroimidazoles found in some drugs and one of the main moieties biological activities exhibited. As an example, we can mention drug benznidazole, only available Brazil treatment Chagas disease. This work describes efficient methodology synthesis 2-nitro-1-vinyl-1H-i...

Crystalline 4-nitro-1-phenylimidazole, C9H7N3O2, (I), and 4'-nitro-1-phenyl-4,1'-biiimidazole, C12H9N5O2, (II), contain C-H...O and C-H...N hydrogen bonds, connecting the molecules into infinite chains. The aromatic fragments in both compounds are nearly planar. The dihedral angles between the benzene and imidazole rings are 26.78 (5) degrees in (I) and 29.36 (8) degrees in (II).

Nitroimidazoles are characterized by a wide range of biological activity and many them used as therapeutics. Moreover, some bicyclic nitroimidazooxazoles show considerable potency against Mycobacterium tuberculosis. Some authors noticed that in the case chiral derivatives nitroimidazodihydrooxazoles, (R) form shows greater tuberculostatic than (S) enantiomer. This work describes procurement new...

Decomposition of three imidazole based model energetic systems (2-nitroimidazole, 4-nitroimidazole, and 1-methyl-5-nitroimidazole) is investigated both experimentally and theoretically. The initial decomposition mechanism for these three nitroimidazoles is explored with nanosecond energy resolved spectroscopy, and quantum chemical theory at the complete active space self-consistent field (CASSC...

Tuberculosis continues to be a global health threat, making bicyclic nitroimidazoles an important new class of therapeutics. A deazaflavin-dependent nitroreductase (Ddn) from Mycobacterium tuberculosis catalyzes the reduction of nitroimidazoles such as PA-824, resulting in intracellular release of lethal reactive nitrogen species. The N-terminal 30 residues of Ddn are functionally important but...

Metronidazole, ornidazole, tinidazole, and secnidazole are 5-nitroimidazoles. The purpose of this work was to propose a new economical TLC–densitometric method evaluate the chemical stability metronidazole, secnidazole, tinidazole under stress conditions. A forced degradation study performed on silica gel aqueous solutions at various pH values; were prepared in saline hydrogen peroxide, respect...

Parasitic and bacterial infections affecting the gastrointestinal tract represent a significant cause of morbidity and mortality worldwide. Nitroheterocyclic drugs have been available since the early 1960s for the treatment of anaerobic protozoa. The application of these drugs has widened and they are presently used to treat anaerobic pathogenic bacteria and protozoa. 5-nitroimidazoles are a we...