The occurrence and formation of N-nitrosamines in water supplies is of concern to the water industry, as N-nitrosamines have been reported to be carcinogenic, mutagenic, and/or teratogenic. The US Environmental Protection Agency’s (USEPA’s) Integrated Risk Information System indicates that N-nitrosodimethylamine (NDMA) is a probable human carcinogen (USEPA 1997). Other N-nitrosamines typically ...

Volatile N-nitrosamines were detected in the urine of male volunteers with gas-liquid and high-pressure liquid chromatography interfaced to the thermal energy analyzer. Of 50 samples from normal males, 10 contained nitrosodimethylamine (0.02 to 0.10 micrograms/liter), 6 contained nitrosodiethylamine (0.02 to 3.10), 9 contained nitrosomorpholine (0.006 to 0.67), and none contained nitrosodibutyl...

Spirits from areas of high and low incidence of cancer of the oesophagus were examined for volatile nitrosamines using a chemiluminescent detector. No nitrosamines were found, the detection limit being 0.001 microng/ml.

Natural organic matter (NOM) in source water originated from Luan River and Yellow River, North China was isolated and fractionated with XAD resins and ultra-filtration membranes. The raw water samples and fractions were disinfected with sufficient monochloramine to determine their N-nitrosamines formation potentials. Fluorescence Excitation-Emission Matrix (EEM), molecular weight (MW), dissolv...

The detection of an oxygen-atom photoexchange process of N-nitrosamines is reported. The photolysis of four nitrosamines (N-nitrosodiphenylamine 1, N-nitroso-N-methylaniline 2, N-butyl-N-(4-hydroxybutyl)nitrosamine 3, and N-nitrosodiethylamine 4) with ultraviolet light was examined in an (18)O2-enriched atmosphere in solution. HPLC/MS and HPLC-MS/MS data show that (18)O-labeled nitrosamines wer...

Nitrosamines are a group of carcinogenic chemicals that are present in aquatic environments that result from byproducts of industrial processes and disinfection products. As indirect and direct potable reuse increase, the presence of trace nitrosamines presents challenges to water infrastructures that incorporate effluent from wastewater treatment. Ultraviolet (UV) photolysis or UV-based advanc...

In view of the complex and cumbersome problems in detection nitrosamines past, this article optimizes method livestock food establishes a more complete nitrosamines. method, solid alkali heat treatment is used instead national standard to pre-treat sample. Then, activated carbon column phase extraction for detection, higher precision recovery rate are obtained, which proved that can be populari...

Eleven household dishwashing liquids and four household surface cleaners were analysed for N-nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine by gas chromatography with detection using a Thermal Energy Analyzer. Both nitrosamines were found in three of the dishwashing detergents and one of the surface cleaners. [1-14C]-N-Nitroso-N-methyldodecylamine was used to determine recov...

This review summarizes major findings over the last decade related to nitrosamines in drinking water, with a particular focus on N-nitrosodimethylamine (NDMA), because it is among the most widely detected nitrosamines in drinking waters. The reaction of inorganic dichloramine with amine precursors is likely the dominant mechanism responsible for NDMA formation in drinking waters. Even when occu...

A sensitive cell-mediated assay has been developed for testing mutagenesis in Chinese hamster V79 cells by carcino genic nitrosamines. Mutations were characterized by resist ance to ouabain and 6-thioguanine. Since V79 cells do not metabolize nitrosamines, mutagenesis in the V79 cells was tested in the presence of primary hepatocytes capable of metabolizing nitrosamines. The hepatocytes were is...