1. Rezvani I, Rezvani GA. An approach to inborn errors of metabolism. In: Kliegman R, Stanton B, St Geme JW, Schor NF, Behrman RE, editors. Nelson Textbook of Pediatrics. 20th ed. Philadelphia: W.B. Saunders Company; 2016. p. 634‐6. 2. Burton BK. Inborn errors of metabolism in infancy: A guide to diagnosis. Pediatrics 1998;102:E69. 3. Sperling MA. Hypoglycemia. In: Kliegman R, Stanton B, St Gem...

extract   when you are faced with a diabetic person that has been numbness, lethargic or confuse condition and likely to enter into a diabetic coma what nursing interventions should be done?   the answer of question is related to complete review of symptoms by nurses. typically, in the most cases hypoglycemia can cause coma. the next cause of coma is diabetic ketoacidosis that occurs with hyper...

As noted recently by Jones et al., hypoglycemia is common in hospitalized patients with cystic fibrosis-related diabetes (CFRD) and is associated with an increase in readmission or death [1]. Though insulin therapy has been blamed for episodes of hypoglycemia, we noted ketonemia (elevated fingerstick 3-hydroxybutyrate) in several hospitalized patients with CFRD and hypoglycemia [2]; serum gluca...

Sir, Inborn errors of metabolism (IEM) are biochemical disorders result from the absence or abnormality of an enzyme or its cofactor, leading to either accumulation or deficiency of a specific metabolite. [1] More than 600 described IEMs have a clear phenotype. [2] However, occasionally a clinical and biochemical phenotype is not completely explained based on known disorder. A clear diagnosis i...

Hepatic carnitine palmitoyltransferase (CPT) turnover was studied in control and in non-ketotic hyperglycaemic streptozotocin-diabetic rats. The degradation constant (kd) and half-life (t1/2) did not appear to be altered by mild diabetes. The hepatic CPT (micrograms/g of liver) was not increased by the mild, non-ketotic, diabetes. However, the total hepatic CPT (micrograms/liver) was 37% greate...

conclusions since most of the symptoms of metabolic diseases in newborns are same as the signs of sepsis or other common diseases of this period, and also early diagnosis and treatment of these illnesses, especially in diseases such as hyperglycemia, can be influential in neural function of babies, it calls for serious attention and clinical vision of the doctors to stop mortality caused by suc...