Based on a previously derived population pharmacokinetic model, a novel neonatal amikacin dosing regimen was developed. The aim of the current study was to prospectively evaluate this dosing regimen. First, early (before and after second dose) therapeutic drug monitoring (TDM) observations were evaluated for achieving target trough (<3 mg/liter) and peak (>24 mg/liter) levels. Second, all obser...

a method has been presented for finding the solution surface of the npde: u  c , bounded by a general space curve. the method is based on the geometric characteristics of the surface, and is called the “cone-slot method”. it has been shown that such a surface can be obtained by movement of a cone inside the slot formed by the boundary space curve. an algorithm has been suggested on the basis ...

INTRODUCTION The pharmacokinetics of vancomycin are highly variable among neonates, which makes dosing challenging in this population. However, adequate drug exposure is critical, especially when treating methicillin-resistant Staphylococcus aureus (MRSA) infections. Utilization of population pharmacokinetic models and Bayesian methods offers the potential for developing individualized therapeu...

In this paper, we apply the Exp-function method to Rosenau-Kawahara and Rosenau-KdV equations. Rosenau-Kawahara equation is the combination of the Rosenau and standard Kawahara equations and Rosenau-KdV equation is the combination of the Rosenau and standard KdV equations. These equations are nonlinear partial differential equations (NPDE) which play an important role in mathematical physics. E...

In this paper Lie’s formalism is applied to deduce classes of solutions of a nonlinear partial differential equation (nPDE) of second order with quadratic nonlinearity. The equation has the meaning of a field equation appearing in the formulation of kinetic models. Similarity solutions and transformations are given in a most general form derived to the first time in terms of reciprocal Jacobian...

in this paper lie’s formalism is applied to deduce classes of solutions of a nonlinear partialdifferential equation (npde) of second order with quadratic nonlinearity. the equation has themeaning of a field equation appearing in the formulation of kinetic models. similaritysolutions and transformations are given in a most general form derived to the first time interms of reciprocal jacobian ell...

A method has been presented for finding the solution surface of the NPDE: c u   , bounded by a general space curve. The method is based on the geometric characteristics of the surface, and is called the “Cone-Slot Method”. It has been shown that such a surface can be obtained by movement of a cone inside the slot formed by the boundary space curve. An algorithm has been suggested on the basis...

the purpose of this paper is to analyze in detail a special nonlinear partial differentialequation (npde) of the second order which is important in physical, chemical and technicalapplications. the present npde describes nonlinear diffusion and is of interest in several partsof physics, chemistry and engineering problems alike. since nature is not linear intrinsicallythe nonlinear case is there...