The peptide welding technology (PWT) is a novel chemical strategy that allows the synthesis of multibranched peptides with high yield, purity, and reproducibility. With this approach, a tetrabranched derivative of neuropeptide S (NPS) has been synthesized and pharmacologically characterized. The in vitro activity of PWT1-NPS has been studied in a calcium mobilization assay. In vivo, PWT1-NPS ha...

objective(s):   metal nanoparticles (nps) offer a wide variety of potential applications in pharmaceutical sciences due to the unique advances in nanotechnology research. in this work, bimetal ag-au alloy nps were prepared and their combinations with other antibiotics were tested against staphylococcus aureus.   materials and methods: firstly, ag-au alloy nps with au/ag molar ratio of 1:1 was f...

In Bošković (2008a) I argue that there is a fundamental structural difference in the traditional Noun Phrase (TNP) of English and article-less languages like SC, which can be captured if DP is not even present in the TNPs in (2) (see also Fukui 1988, Corver 1992, Zlatić 1997, Chierchia 1998, Cheng and Sybesma 1999, Lyons 1999, Willim 2000, Baker 2003, among others for no-DP analyses of at least...

The Net Promoter Score (NPS) is, according to Reichheld, the single most reliable indicator of company growth, and many companies use this recommendation-based technique for measuring customer loyalty. Despite its widespread adoption by many companies across multiple industries, the debate about NPS goes on. A major concern is that managers treat NPS as being equivalent across customers, which ...

Both folic acid (FA)- and methoxypoly(ethylene glycol) (mPEG)-conjugated chitosan nanoparticles (NPs) had been designed for targeted and prolong anticancer drug delivery system. The chitosan NPs were prepared with combination of ionic gelation and chemical cross-linking method, followed by conjugation with both FA and mPEG, respectively. FA-mPEG-NPs were compared with either NPs or mPEG-/FA-NPs...

background and aims: although metal and metal oxide nanoparticles are used in different medical applications, they may have considerable toxicity on various cells, such as myocytes. therefore, this study aimed to evaluate the toxicity of the naked and serum-treated silver nanoparticles (ag nps) and magnesium oxide nanoparticles (mgo nps) on the cardiomyocytes. materials and methods: cardiomyocy...

in addition to its antioxidant effect, vitamin e or α–tocopherol is suggested to enhance remyelination in the animal model of non-inflammatory demyelination. in this study, the possible proliferative effect of vitamin e on human- induced pluripotent stem cell-derived neural progenitors (hips-nps) and the underlying mechanisms were investigated in vitro. nps were induced from ips cells via 3 ste...

manganese zinc ferrite nanoparticles (mzf nps) were synthesized by using a direct, efficient and environmental friendly hydrothermal method. to improve the colloidal stability of mzf nps for biomedical applications, nps were coated with chitosan by ionic gelation technique using sodium tripolyphosphate (tpp) as crosslinker. the synthesized nps were characterized by x ray diffraction (xrd) analy...

Nematode Caenorhabditis elegans has been developed in a variety of environmental studies to address adverse effects of a wide range of toxicants. In the present study, we compared the toxicities of three metal oxide nanoparticles (NPs) including TiO(2)-NPs, ZnO-NPs, and SiO(2)-NPs with the same nanosize (30 nm) after prolonged exposure from L1-larvae to adult at environmental relevant concentra...