Hsa is a large, serine-rich protein of Streptococcus gordonii DL1 that mediates binding to α2-3-linked sialic acid termini of glycoproteins, including platelet glycoprotein Ibα, and erythrocyte membrane protein glycophorin A, and band 3. The binding of Hsa to platelet glycoprotein Ibα contributes to the pathogenesis of infective endocarditis. This interaction appears to be mediated by a second ...

Single-channel currents were recorded from mouse NR1-NR2B (zeta-epsilon2) receptors containing mixtures of wild-type and mutant subunits expressed in Xenopus oocytes. Mutant subunits had an asparagine-to-glutamine (N-to-Q) mutation at the N0 site of the M2 segment (NR1:598, NR2B:589). Receptors with pure N or Q NR1 and NR2 subunits generated single-channel currents with distinctive current patt...

1 [Adjr2, {r2}, {whiter2}] (whiter2) 2 [Adjr2,U, ∅] (nopr2) 3 [Nr2, {r2}, {whiter2, rabbit r2}] (rabbit r2, 1) 4 [Nr2, {r2}, {whiter2}] (thingr2, 1) 5 [Nr2, {r1, r2}, {rabbit r2}] (rabbit r2, 2) 6 [NPr2, {r2}, {whiter2, rabbit r2}] (ther2, 3) 7 [NPr2, {r2}, {whiter2}] (ther2, 4) 8 [NPr2, {r1, r2}, {rabbit r2}] (ther2, 5) 9 [Se, {e}, {whiter2, rabbit r2, sleepe,r2}] (sleepe,r2, 6) 10 [Se, {e}, {...

Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system, and the N-methyl-D-aspartate-selective glutamate receptor (NR) consisting of the NR1 subunit and an NR2 or NR3 subunit plays crucial roles in synaptic transmission, plasticity, and learning and memory. By using a knockout mouse strain, in which the NR1 gene deletion is primarily targeted to the CA1 pyramid...

The time course of the assembly of the N-methyl-D-aspartate receptor was examined in a cell line expressing it under the control of the dexamethasone promoter. These studies suggested a delay between the appearance of the NR1 and NR2A subunits and their stable association as examined by co-immunoprecipitation of NR1 and NR2A. This prompted us to examine the stability and folding of the individu...

Mononuclear [Ir{ArNC(NR2)NAr}(C8H14)2] complexes (where R = Me or Et; Ar = Ph or 4-MeC6H4; and C8H14 = cis-cyclooctene) were synthesized from the neutral N,Ndialkyl-N′,N′′-diarylguanidines via deprotonation and transmetalation. As confirmed by single-crystal structure determination, the guanidinato(1−) ligands coordinate the lowvalent d Ir center in an N,N′-chelating binding mode, and the C−N d...

The cytoplasmic C-terminal domains of NR2 subunits have been proposed to modulate the assembly and trafficking of NMDA receptors. However, questions remain concerning which domains in the C terminus of NR2 subunits control the assembly of receptor complexes and how the assembled complexes are selectively trafficked through the various cellular compartments such as endoplasmic reticulum (ER) to ...

Schizophrenia is a debilitating neurodevelopmental psychiatric disorder. Both the N-methyl-D-aspartate receptor (NMDAR) and neuregulin1 (NRG1) are key molecules involved in normal brain development that have been linked to schizophrenia pathology and aetiology. The NR2 proteins are critical structural and functional subunits of the NMDAR and are developmentally and spatially regulated. Altered ...

ion. To test the thermodynamic favourability of the proposed 1e reduction to form 4, we investigated its electrochemistry by cyclic voltammetry. The cyclic voltammogram of 4 in THF reveals a redox feature centred at 0.53 V at 200 mV s 1 (vs. Fc/Fc; see Fig. S23 in ESI†). This feature is marked by a large difference between the potentials of the oxidation and reduction peaks (i.e., 0.72 V at 200...

trans-Bis(alkynyl)palladium complexes, trans-[(PEt3)2Pd(-CtCC{dO}NR2)2] (NR2 = NMe2 (2a), N(CH2)4 (2b)), were synthesized by two different methods: (a) by copper-catalyzed reaction of HCtCC(dO)NR2with [PdCl2(PEt3)2] under basic conditions and (b) by treatingHCtCC(dO)NR2 with AgNO3 followed by transmetalation of the alkynyl ligand from silver to [PdCl2(PEt3)2]. The reaction of AgCtCC(dO)NMe2 (3a...