backround: we aimed to evaluate analgesic efficacy, opioid-sparing, and opioid-related adverse effects of intravenous paracetamol and intravenous dexketoprofen trometamol in combination with iv morphine after total abdominal hysterectomy. materials and methods: sixty american society of anesthesiologist physical status classification i-ii patients scheduled for total abdominal hysterectomy were...

Although studies have examined the association between nonsteroidal anti-inflammatory drugs (NSAIDs) use and central nervous system (CNS) tumors risk, the results are inconclusive. Here, we conducted a dose-response meta-analysis in order to investigate the correlation between NSAIDs use and CNS tumors risk. Up to July 2017, 12 studies were included in current meta-analysis. NSAIDs use was sign...

tendons are frequently targets of injury in sports and work. whether nonsteroidal anti-inflammatory drugs (nsaids) have beneficial effects on tendon healing is still a matter of debate. this study was conducted to evaluate effects of flunixin meglumine (fm) on tendon healing after experimentally induced acute trauma. twenty eight adult male new zealand white rabbits were subjected to complete t...

27 Urinary bladder cancer prevention studies were performed with the nonsteroidal anti28 inflammatory drugs (NSAIDs) naproxen (a standard NSAID with a good cardiovascular profile), 29 sulindac, and their nitric oxide (NO) derivatives. Additionally, the effects of the ornithine 30 decarboxylase inhibitor, difluoromethylornithine (DFMO), alone or combined with a suboptimal 31 dose of naproxen or ...

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are the common analgesics, antipyretics, and drugs. Though, their frequent consumption cause peptic ulcer disease (PUD) other unfavorable side effects. This study aimed to compare knowledge attitude of Karachi medical non-medical students about NSAIDs adverse Methods: A comparative cross-sectional was conducted from June 2021-2022, incl...

Nonsteroidal anti-inflammatory drugs (NSAIDs) have long been used to treat pain, fever, and inflammation. However, mounting evidence shows that NSAIDs, such as aspirin, have very promising antineoplastic properties. The chemopreventive, antiproliferative behaviour of NSAIDs has been associated with both their inactivation of cyclooxygenases (COX) and their ability to induce apoptosis via pathwa...

Topical administration of non-steroidal anti-inflammatory drugs (NSAIDs) is generally considered safer than oral administration, although the former can occasionally induce cutaneous irritation. We hypothesized that the cutaneous irritation by topical NSAIDs might be suppressed by trehalose, which has protective effects on biological membranes. Using the three-dimensional cultured human skin mo...