نتایج جستجو برای: nspcs

تعداد نتایج: 139  

2016
Mandi J. Corenblum Sneha Ray Quentin W. Remley Min Long Bryan Harder Donna D. Zhang Carol A. Barnes Lalitha Madhavan

Although it is known that the regenerative function of neural stem/progenitor cells (NSPCs) declines with age, causal mechanisms underlying this phenomenon are not understood. Here, we systematically analyze subventricular zone (SVZ) NSPCs, in various groups of rats across the aging spectrum, using in vitro and in vivo histological and behavioral techniques. These studies indicate that although...

2011
Howard Kim Tasneem Zahir Charles H. Tator Molly S. Shoichet

Neural stem/progenitor cells (NSPCs) have great potential as a cell replacement therapy for spinal cord injury. However, poor control over transplant cell differentiation and survival remain major obstacles. In this study, we asked whether dibutyryl cyclic-AMP (dbcAMP), which was shown to induce up to 85% in vitro differentiation of NSPCs into neurons would enhance survival of transplanted NSPC...

2013
Shigeki Ohta Aya Misawa Véronique Lefebvre Hideyuki Okano Yutaka Kawakami Masahiro Toda

Macrophage migration inhibitory factor (MIF) has important roles in supporting the proliferation and/or survival of murine neural stem/progenitor cells (NSPCs), but downstream effectors remain unknown. We show here that MIF robustly increases the expression of Sox6 in NSPCs in vitro. During neural development, Sox6 is expressed in the ventricular zone of the ganglionic eminence (GE) of mouse br...

2017
Alexey Yu Lupatov Rimma A Poltavtseva Oxana A Bystrykh Konstantin N Yarygin Gennady T Sukhikh

Cell therapy of the nervous system disorders using neural stem/progenitor cells (NSPCs) proved its efficacy in preclinical and pilot clinical studies. The mechanisms of the beneficial effects of NSPCs transplantation include replacement of damaged cells, paracrine activation of the regeneration, and immunomodulation. Detailed assessment of NSPCs-induced immunomodulation can contribute to better...

2016
Hongfei Ge Anyong Yu Jingyu Chen Jichao Yuan Yi Yin Wangsheng Duanmu Liang Tan Yang Yang Chuan Lan Weixiang Chen Hua Feng Rong Hu

The recruitment of neural stem/progenitor cells (NSPCs) for brain restoration after injury is a promising regenerative therapeutic strategy. This strategy involves enhancing proliferation, migration and neuronal differentation of NSPCs. To date, the lack of biomaterials, which facilitate these processes to enhance neural regeneration, is an obstacle for the cell replacement therapies. Our previ...

2013
Nobuyuki Sakayori Ryuichi Kimura Noriko Osumi

The neural system originates from neural stem/progenitor cells (NSPCs). Embryonic NSPCs first proliferate to increase their numbers and then produce neurons and glial cells that compose the complex neural circuits in the brain. New neurons are continually produced even after birth from adult NSPCs in the inner wall of the lateral ventricle and in the hippocampal dentate gyrus. These adult-born ...

2017
Nicoletta Carucci Emanuele Cacci Paola S Nisi Valerio Licursi Yu-Lee Paul Stefano Biagioni Rodolfo Negri Peter J Rugg-Gunn Giuseppe Lupo

During vertebrate neural development, positional information is largely specified by extracellular morphogens. Their distribution, however, is very dynamic due to the multiple roles played by the same signals in the developing and adult neural tissue. This suggests that neural progenitors are able to modify their competence to respond to morphogen signalling and autonomously maintain positional...

2010
Kate M. Harms Lu Li Lee Anna Cunningham

Focal cerebral ischemia following middle cerebral artery occlusion (MCAO) stimulates a robust cytogenic response from the adult subventricular zone (SVZ) that includes massive proliferation of neural stem/progenitor cells (NSPCs) and cellular migration into the injury area. To begin to explore beneficial roles of NSPCs in this response, we investigated the ability of embryonic and postnatal NSP...

2015
Hongfei Ge Liang Tan Pengfei Wu Yi Yin Xin Liu Hui Meng Gaoyu Cui Nan Wu Jiangkai Lin Rong Hu Hua Feng

Neural stem/progenitor cells (NSPCs) replacement therapies are the most attractive strategies to restore an injured brain. Key challenges of such therapies are enriching NSPCs and directing them differentiation into specific neural cell types. Here, three biomaterial substrates Poly-L-ornithine (PO), Poly-L-lysine (PLL) and fibronectin (FN) were investigated for their effects on proliferation a...

Journal: :Brain Research Bulletin 2017
Kisha Greer Jiang Chen Thomas Brickler Robert Gourdie Michelle H. Theus

Restoration of learning and memory deficits following traumatic brain injury (TBI) is attributed, in part, to enhanced neural stem/progenitor cell (NSPCs) function. Recent findings suggest gap junction (GJ)-associated connexin 43 (Cx43) plays a key role in the cell cycle regulation and function of NSPCs and is modulated following TBI. Here, we demonstrate that Cx43 is up-regulated in the dentat...

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