نتایج جستجو برای: nuclear factor κ b nfκ b

تعداد نتایج: 1818504  

2014
Xian-Long Zhou Wei Fan Gui Yang Ming-Xia Yu

OBJECTIVES To investigate the expression of estrogen (ER), progesterone receptors (PR), nuclear factor- κ B (NF- κ B), and tumor necrosis factor- α (TNF- α ) in human breast cancer (BC), and the correlation of these four parameters with clinicopathological features of BC. METHODS AND RESULTS We performed an immunohistochemical SABC method for the identification of ER, PR, NF- κ B, and TNF- α ...

2013
Bing-rong Zhou Jia-an Zhang Qian Zhang Felicia Permatasari Yang Xu Di Wu Zhi-qiang Yin Dan Luo

To investigate whether palmitic acid can be responsible for the induction of inflammatory processes, HaCaT keratinocytes were treated with palmitic acid at pathophysiologically relevant concentrations. Secretion levels of interleukin-6 (IL-6), tumor necrosis factor- α (TNF- α), interleukin-1 β (IL-1 β), NF- κ B nuclear translocation, NF- κ B activation, Stat3 phosphorylation, and peroxisome pro...

2013
Olumayokun A. Olajide Harsharan S. Bhatia Antonio C. P. de Oliveira Colin W. Wright Bernd L. Fiebich

Cryptolepine, an indoloquinoline alkaloid in Cryptolepis sanguinolenta, has anti-inflammatory property. In this study, we aimed to evaluate the effects of cryptolepine on lipopolysaccharide (LPS)- induced neuroinflammation in rat microglia and its potential mechanisms. Microglial activation was induced by stimulation with LPS, and the effects of cryptolepine pretreatment on microglial activatio...

Journal: :BMB reports 2012
Sun Hwa Lee Dae Won Kim Seon Ae Eom Se-Young Jun Meeyoung Park Duk-Soo Kim Hyung Joo Kwon Hyeok Yil Kwon Kyu Hyung Han Jinseu Park Hyun Sook Hwang Won Sik Eum Soo Young Choi

We examined that the protective effects of ANX1 on 12-O-tetradecanoylphorbol- 13-acetate (TPA)-induced skin inflammation in animal models using a Tat-ANX1 protein. Topical application of the Tat-ANX1 protein markedly inhibited TPAinduced ear edema and expression levels of cyclooxygenase-2 (COX-2) as well as pro-inflammatory cytokines such as interleukin- 1 beta (IL-1 β), IL-6, and tumor necrosi...

2013
Mrinalini Singh Rajkumar Tulsawani Praveen Koganti Amitabh Chauhan Manimaran Manickam Kshipra Misra

Cordyceps sinensis, an edible mushroom growing in Himalayan regions, is widely recognized in traditional system of medicine. In the present study, we report the efficacy of Cordyceps sinensis in facilitating tolerance to hypoxia using A549 cell line as a model system. Treatment with aqueous extract of Cordyceps sinensis appreciably attenuated hypoxia induced ROS generation, oxidation of lipids ...

2013
Xiao-Hong Li Kristine C. Y. McGrath Van H. Tran Yi-Ming Li Colin C. Duke Basil D. Roufogalis Alison K. Heather

Introduction. Hepatic inflammation underlies the pathogenesis of chronic diseases such as insulin resistance and type 2 diabetes mellitus. S-[6]-Gingerol has been shown to have anti-inflammatory properties. Important inflammatory mediators of interleukins include nuclear factor κ B (NF κ B) and cyclooxygenase 2 (COX2). We now explore the mechanism of anti-inflammatory effects of S-[6]-gingerol ...

2013
Seung-Won Park Chunghee Cho Byung-Nam Cho Youngchul Kim Tae Won Goo Young Il Kim

15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) and activin are implicated in the control of apoptosis, cell proliferation, and inflammation in cells. We examined both the mechanism by which 15d-PGJ2 regulates the transcription of activin-induced activin receptors (ActR) and Smads in HepG2 cells and the involvement of the nuclear factor- κ B (NF- κ B) and mitogen-activated protein kinase (MAPK) p...

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