The phenomena of shape evolution and coexistence in even-even $^{88-126}$Zr $^{88-126}$Mo isotopes is studied by employing covariant density functional theory (CDFT) with density-dependent point coupling parameter sets DD-PCX DD-PC1, separable pairing interaction. results for rms deviation binding energies, two-neutron separation energy, the differential variation charge radii, as a function ne...

Every student of muscle ultrastructure is familiar with the frequently convoluted appearance of the muscle cell nucleus (e .g . Figs . 1-3) . It is a reasonable assumption that this particular shape of the nucleus can be correlated with the contracted state of the muscle fiber . Lane (12) was able to show that in contracting intestinal smooth muscle cells the nucleus undergoes a change from an ...

In eukaryotic cells, the nucleus contains the genome and is the site of transcriptional regulation. The nucleus is the largest and stiffest organelle and is exposed to mechanical forces transmitted through the cytoskeleton from outside the cell and from force generation within the cell. Here, we discuss the effect of intra- and extracellular forces on nuclear shape and structure and how these f...

The empirical characterization of nuclear shape distributions is an important unsolved problem with many applications in biology and medicine. Numerous genetic diseases and cancers have alterations in nuclear morphology, and methods for characterization of morphology could aid in both diagnoses and fundamental understanding of these disorders. Automated approaches have been used to measure feat...

Changes in nuclear morphology occur during normal development and have been observed during the progression of several diseases. The shape of a nucleus is governed by the balance of forces exerted by nuclear-cytoskeletal contacts and internal forces created by the structure of the chromatin and nuclear envelope. However, factors that regulate the balance of these forces and determine nuclear sh...

We report crosstalk between three senescence-inducing conditions, DNA damage response (DDR) defects, oxidative stress (OS) and nuclear shape alterations. The recessive autosomal genetic disorder Ataxia telangiectasia (A-T) is associated with DDR defects, endogenous OS and premature ageing. Here, we find frequent nuclear shape alterations in A-T cells, as well as accumulation of the key nuclear ...