The first isolation of what we now refer to as DNA was accomplished by Johann Friedrich Miescher circa 1870. He reported finding a weakly acidic substance of unknown function in the nuclei of human white blood cells, and named this material "nuclein". A few years later, Miescher separated nuclein into protein and nucleic acid components. In the 1920's nucleic acids were found to be major compon...

In: Dyer A, Hudson HG and Williams PA (eds) Ion Exchange Processes: Advances and Applications, p. 39. Cambridge, UK: The Royal Society of Chemistry. Lehto J and Harjula R (1997) Selective separation of radionuclides from nuclear waste solutions with inorganic ion exchangers, React Funct Polym (in press). Navratil JD (1989) Ion exchange technology in spent fuel reprocessing. Journal of Nuclear S...

E wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest. A structure for nucleic acid has already been proposed by Pauling and Corey. They kindly made their manuscript available to us in advance of publication. Their model consists of three intertwined chains, with the phosphates near the fi...

Introduction: Low-energy helium-neon (He-Ne) laser beam lightis used in combination with sodium hypochlorite (Na2HOCl3) for clinical purposes. Regarding this, the present study aimed to investigate the effect of He-Ne laser (632.8 nm) and sodium hypochlorite on the calf thymus double-stranded deoxyribonucleic acid (ctdsDNA) molecule.  Materials and Methods: For the purpose of the study, ctdsDNA...

aptamers define a new interesting class of receptor molecules with capability of binding to potentially any kind of molecules of interest. structurally, they are composed of nucleic acids (rna, dna or a mixture of both) with high specificity and affinity to amino acids, drugs, proteins and other molecules. apatmers are isolated from complex libraries of synthetic nucleic acids against the desir...

Nucleic acids are biologically active materials, and chemically modified nucleic acids are now being used in nucleic acid drugs. DNA, one of the two types of nucleic acids, can also be used as a material to construct DNA-based delivery systems, such as DNA hydrogel, for therapeutic compounds. Use of chemically modified nucleic acids would greatly increase the therapeutic potency of such DNA-bas...