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in this research, samples were collected from three iranian native dogs and three wolves. whole-genome sequencing for each individual was performed using next-generation sequencing technology. all short reads were aligned to the reference genome using bwa tool. single-nucleotide polymorphisms (snps) and small insertions and deletions (indels) were detected using the genome analysis toolkit (gat...

The Single Nucleotide Polymorphisms (SNP) Discovery on Transcriptome of Pure Sistani and Cross-Breeding Holstein, Simmental Monte Billiard Bulls

Background: Thousands of genes are involved in spermatogenesis. Alterations in any of these genes could lead to male infertility. Moloney leukemia virus 10-Like 1 (Mov10l1) gene is one of the genes that are expressed specifically in germ cells. Genetic disruption of this gene in mouse stops spermatogenesis during Meiosis I and causes azoospermia. Materials and Methods: In this study, the geneti...

the relation between single nucleotide polymorphisms (snps) and some diseases has been concerned by many researchers. also the missing snps are quite common in genetic association studies. hence, this article investigates the relation between existing snps in dnmt1 of human chromosome 19 with colorectal cancer. this article aims is to presents an imputation method for missing snps not at random...

background esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (git) neoplasms, causing almost two million deaths worldwide each year. some environmental risk factors are acknowledged; however, genetic defects can significantly contribute to predisposition to git cancers. accordingly, recent works have shown that single-nucleotide polymorphisms (snps) within m...

purpose: neuromyelitis opitca (nmo) is an autoimmune disease that relates to deposition of anti-aquaporin-4 (aqp4) igg in the central nervous system (cns). however, called seronegative nmo when patients are negative for aqp4 antibody. nevertheless, nmo is most probably an antibody mediated disease. the aim of this study was to assess the association between seronegative nmo disease and variatio...

mannose-binding lectin (mbl) is a ca⁺² -dependent collagenous lectin, that is produced by liver and mediates innate immune responses by opsonization of pathogens. the serum level of mbl varies widely among healthy individuals, ranging from 0.05 µg/ml (or lower) to over 5 µg/ml, mainly depending on genetic variation. this study has examined promoter and exon 1 of mbl2 genotype among 117 iranian ...