background: proliferation and expansion of cancer stem cells as spheroids were proved in previous studies. but, capability of primary tumor-derived stem cells to keep their unique properties in vitro is still disputed. so, the goal of this study was to isolate, expand and characterize of colon cancer-derived stem cells. material and methods: in the present work, colon cancer stem cells markers ...

Cellular hair growth therapy is an emerging approach to alopecia. Recently, Tsuboi et al. (J Am Acad Dermatol. 2020;83,109–116.) have observed hair-growth stimulation by dermal-sheath-cup cells in patients with androgenic Hair follicle-associated pluripotent (HAP) stem cells, originate the bulge area and express nestin, been shown differentiate multiple cell types including keratinocytes, neuro...

two new potential magnetic resonance imaging contrast agents, gd-hematoporphyrin (gd-h) and gd-tetra-carboranylmethoxyphenyl-porphyrin (gd tcp), were synthesized and applied to nude mice with human melanoma (mm 138) xenografts. these agents showed a high relaxivity because of their greater potential to coordinate water molecules. the reduction of t1 relaxation times of 16 and 21% was observed i...

BACKGROUND Nude mice are used in human xenograft research; however, only 25-35% of human tumors have been successfully transplanted into nude mice and their application is limited due to high natural killer (NK) cell activity. More severely immunodeficient mice with loss of NK activity are needed to overcome this limitation. MATERIALS AND METHODS Balb/c nude Rag-2(-/-)Jak3(-/-) (Nude-RJ) mice...

In previous reports, nude mice have demonstrated residual immunoreactivity against xenografts. Severe combined immunodeficient (SCID) mice lack functional T- and B-cells. These animals are expected to be better hosts in which to perform preclinical studies on human tumors. The purpose of this study is to quantitate the advantage of SCID mice over nude mice in terms of transplantability of human...

Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice with normal fetal liver failed. The so-called thymic rudiment of nude mice when grafted to normal mice did not develop thymoc...