type 2 diabetes is one of the major public health challenges in 21st century. both environmental changes and genetics are attributed for increased risk of type 2 diabetes. obesity is the most critical and modifiable risk factor and should be targeted for successful management of diabetes. this review article discusses three main approaches to manage obesity. three management modalities consider...

noncommunicable diseases pose a real threat to and their incidence is forecast to increase in both developed and developing countries; and, diabetes, obesity, and related complications are predicted to pose a great burden on health care systems all across the world. however, current used conventional medications and surgical interventions fall short of effectively controlling the rampant spread...

in the past 40 years there has been drastic increase in the prevalence of obesity worldwide (1). This rapid increase in the prevalence of obesity is not a matter of physiologic or metabolic alteration within people. Thousands of scientific papers are published each year indicating that pharmaceutical companies are working to find possible money making antiobesity agents. Increasing in the preva...

Background: Obesity is pandemic worldwide and a strong risk factor for cardio-metabolic disorders. The few approved anti-obesity drugs have poor efficacy and safety profile. Thus, there is an urgent need for new anti-obesity agents. According to the traditional medicine and a clinical trial, saffron may have anorexigenic and anti-obesity effects which need further investigation. Objectives: Ev...

Obesity is a major epidemic that poses a worldwide threat to human health, as it is also associated with metabolic syndrome, type 2 diabetes and cardiovascular disease. Therapeutic intervention through weight loss drugs, accompanied by diet and exercise, is one of the options for the treatment and management of obesity. However, the only approved anti-obesity drug currently available in the mar...

This review offers an overview of physiological agents, current therapeutics, as well as medications, which have been extensively used and those agents not currently available or non-classically considered anti-obesity drugs. As obesity - particularly that of central distribution - represents an important triggering factor for insulin resistance, its pharmacological treatment is relevant in the...

Obesity is an increasingly serious socioeconomic and clinical problem. Between (1/4)-(1/3) of population in the developed countries can be classified as obese. Four major etiological factors for development of obesity are genetic determinants, environmental factors, food intake and exercise. Obesity increases the risk of the development of various pathologic conditions including: insulin-resist...