Ocular drug delivery is a very challenging area for ophthalmologists and scientists due to the structural barrier complexity of eye. Barriers such as different layers cornea, sclera, conjunctival blood flow, tear dilution limit efficacy anterior part eye in addition more barriers present posterior part. Due these, have designed studied various systems increase treatment Among conventional ocula...

The aim of this study was to test the use of BioCornea, a fish scale-derived collagen matrix for sealing full-thickness corneal perforations in mini-pigs. Two series of experiments were carried out in 8 Lan-Yu and 3 Göttingen mini-pigs, respectively. A 2mm central full thickness corneal perforation was made with surgical scissors and 2mm trephines. The perforations were sealed immediately by su...

Despite numerous scientific efforts many challenges need to be overcome in the ocular delivery because eyes have special and complex anatomic structures. The main problem with the conventional dosage forms is poor ocular bioavailability due to minimum ocular residence time, because of various anatomical and pathophysiological barriers prevailing in the eye. For this reason, much effort has been...

The aim of the present study was to compare conventional radial keratotomy (RK) with minimally invasive RK (mini-RK) in terms of achieved incisional depth as well as the histopathologic changes in the rabbit corneal structures. Four conventional RK incisions were performed on the right eye and four mini-RK incisions were performed on the left eye of 12 Island rabbits using a centripetal cutting...

A scleral contact lens lies on the sclera, not cornea, which differs from a rigid gas permeable (RGP) lens, and has shown successful clinical outcomes in patients unable to tolerate glasses or RGP lenses because of severely deformed cornea. In addition, forms tear film between cornea that stabilizes ocular surface could be useful therapeutic option. The mini-scleral is option for visual improve...

In vivo confocal microscopy (IVCM) is an emerging technology that provides minimally invasive, high resolution, steady-state assessment of the ocular surface at the cellular level. Several challenges still remain but, at present, IVCM may be considered a promising technique for clinical diagnosis and management. This mini-review summarizes some key findings in IVCM of the ocular surface, focusi...

The article presents the modern treatment with stem cells in the reconstruction of ocular surface. The turnover of the stem cells, the location in the limbus areas, the importance of limbal stem cells presence, the clinical appearance of stem cell deficiency, investigations method for this illness and the management of stem cell deficiency (artificial lacrimal tear drops, mini scleral contact l...

This mini review contains a brief update on the pathogenicity of Staphylococcus epidermidis in ocular infections and it’s capability of biofilm formation and adhesion on the materials used in intraocular lens implants in cataract surgery patients. The review also gives an update on the genetic and molecular aspects in the understanding of biofilm formation by S. epidermidis strains on medical i...

PurposeTo determine the mechanism behind macular bulge height increase in eyes with dome-shaped macula (DSM).DesignRetrospective, observational case series.MethodsEyes presenting DSM followed up for a minimum of 1 year were examined using ocular biometry and spectral-domain optical coherence tomography at baseline end follow-up. Axial length (AL), height, central peripheral choroidal thickness ...

One of the major concerns in any pharmacological treatment is patients’ adherence to medication. However, different types ocular dosage forms might result response and compliance from patients. This study investigated compared public willingness on available for treatment. The also evaluated their new approach based knowledge, attitude, perception. was conducted between October December 2017 th...