HN Shivakumar, et al., (2007), Fabricated & evaluation of pH sensitive Minitablets for chronotherapeutic delivery of theophylline using different coat weights of eudragit S-100 to be applied to the drug loaded core mini-tablets. The study showed that the coat weight of 10% weight gain was sufficient to impart an excellent gastro resistant property to the tablets for effective release of the dru...

Abstract Background The current study expands on the use of design experiment in developing cefuroxime axetil mucoadhesive minitablets for treating antibiotic-associated colitis. A comprehensive QbD-based product development strategy was implemented, with target profile defined based desired quality minitablets. identified critical attributes are profile. goal to find optimum levels by using co...

Theophylline is a methylxanthine drug used in therapy for respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. A chronotherapeutic approach towards asthma management is particularly important, as bronchial asthma attacks follow circadian rhythms, since they appear more often during the night and/or early in the morning. Many chronotherapeutic studies have shown...

purpose: controversy has recently risen about the presence of compensatory ocular countertorsion (coct) after head tilt. this study was performed to define the functional range of this phenomenon. methods: cycloplegic autorefraction was performed on 80 eyes with regular astigmatism 2d. objective autorefraction was performed in normal position, right and left head tilt positions of 5º, 10º, 15º,...

A randomized crossover study of 5-g guar minitablets against placebo, given three times per day with main meals for 8 wk, was done in 29 non-insulin-dependent diabetes mellitus (NIDDM) patients who had near-normal fasting plasma glucose concentrations on treatment with diet alone, additional sulfonylurea, or ultralente insulin. Guar did not reduce the excessive postprandial glycemic excursion, ...

Mutilation in the facial region may significantly affect the self-image and personality of individuals. Prosthetic rehabilitation of facial defects could increase the quality of life, thereby encouraging the patients to build up their self-confidence to return to normal social life. Acceptable cosmetic results are often obtained through facial prosthesis. Recovery after the loss of an eye requi...