Proposed by Lee and Hirst, the phrase ocular surface squamous neoplasia (OSSN) includes the clinical continuum of mild, moderate, and severe dysplasia, carcinoma in situ, and invasive squamous cell carcinoma (SCC).[1] It is important to understand that dysplasia and carcinoma in situ, together constituting conjunctival intraepithelial neoplasia (CIN), are premalignant by definition, and SCC is ...

AIM To report the outcome of topical mitomycin C (MMC) used as adjunctive treatment following primary excision of ocular surface squamous neoplasia (OSSN). METHOD Prospective, non-comparative interventional case series of 27 primary OSSN lesions from 26 patients treated in a single ocular oncology centre over a 4 year period. RESULT 27 cases of OSSN received a treatment regimen of surgical ...

Purpose. Pseudoepitheliomatous hyperplasia at the limbus can mimic an ocular surface squamous neoplasia. It is an uncommon manifestation of vernal keratoconjunctivitis and has been reported previously in limbal VKC. It, however, has not been reported as a manifestation in the palpebral form of the disease and needs to be kept in the differential diagnosis of a limbal mass lesion in vernal kerat...

the past decade has witnessed the revival of amniotic membrane transplantation (amt) in ophthalmology. the importance of amt is due to its ability to reduce scarring and inflammation and to enhance wound healing and epithelialization, and also its anti-microbial properties. amniotic membrane has recently been used as a substrate for culturing limbal stem cells for transplantation. it has been u...

Ocular surface squamous neoplasia (OSSN) is the most common type of ocular tumour. An eighty-year-old man with an elevated lesion in right eye was diagnosed to have OSSN. 1% topical 5-FU started as intermittent treatment. Examination during each visit showed consistent reduction size lesion. The patient complete regression no recurrence following treatment at 3 months from presentation. Tropica...