BACKGROUND The neuropathological process underlying amyotrophic lateral sclerosis (ALS) can be traced as a four-stage progression scheme of sequential corticofugal axonal spread. The examination of eye movement control gains deep insights into brain network pathology and provides the opportunity to detect both disturbance of the brainstem oculomotor circuitry as well as executive deficits of oc...

Oculomotor nerve palsy frequently occurs because of external compression by an internal carotid-posterior communicating artery aneurysm and diabetes mellitus. In addition, pontine infarction, cavernous sinus tumors, demyelinating disease, and autoimmune disorder are well-known causes of oculomotor nerve palsy. However, cases of complete oculomotor nerve palsy by neurovascular conflicts presente...

PURPOSE To compare the MR characteristics of the oculomotor nucleus with its appearance on anatomic images. METHODS Specimens of cadaveric brains were imaged in a 3.0-T MR imager equipped with a 3.0-cm solenoid coil. The specimens were sectioned, stained, and examined histologically. On anatomic sections, the oculomotor nuclei, medial longitudinal fasciculus, red nuclei, and oculomotor nerve ...

Neuroanatomical Organization of the Anuran Mesencephalon and Brainstem Pathways Related to Oculomotor Function May 1984 Neil M. Montgomery, B.A., University of Massachusetts M.S., University of Massachusetts Ph.D., University of Massachusetts Directed by: Dr. Katherine V. Fite The neuroanatomical organization of the anuran oculomotor system was investigated using the Golgi and horseradish perox...

Although oculomotor nerve palsy, which is common in diabetes, is considered an ischemic mononeuropathy, the susceptibility of the oculomotor nerve to ischemic insult is not well understood. We analyzed the density of endoneurial microvessels of the oculomotor nerve and compared it with that of the sural nerve in non-diabetic patients. The mean vascular density of the oculomotor nerve (23 ± 8.4/...

Departament of Neurosurgery, Instituto de Neurologia de Curitiba, Curitiba PR, Brazil; Department of Neurology, Instituto de Neurologia de Curitiba, Curitiba PR, Brazil; Neurological Clinic of Paraíba, João Pessoa PB, Brazil. Oculomotor nerve palsy is frequently caused by an aneurismal compression and diabetes mellitus. Brainstem infarction, cavernous sinus tumors and other intracranial lesions...

A 37-year-old woman presented with an extremely rare large oculomotor schwannoma associated with acute hydrocephalus manifesting as semicoma and anisocoria. Brain computed tomography and magnetic resonance imaging revealed a tumor in the oculomotor cistern. Cerebral angiography revealed separation of the posterior cerebral artery (PCA) and superior cerebellar artery (SCA). The tumor was removed...