Methods: Ninety pigs randomly assigned to five groups were vaccinated intramuscularly at 4 and 6 weeks of age with 2 mL of a commercial Mycoplasma hyopneumoniae (M hyo) vaccine with oil-in-water adjuvant (Group 1), a commercial M hyo vaccine with an aqueous-carbopol adjuvant (Group 2), an experimentally produced M hyo vaccine with an oil-in-water adjuvant (Group 3), or an experimentally produce...

Abstract Background and Aims: Vaccination of poultry has a major impact on the prevention and control of avian influenza viruses. Nanobiotechnology techniques provide a new approach for improvement of influenza vaccine efficacy. In this study, efficacy of an inactivated nano-adjuvant vaccine developed based on an endemic H9N2 virus was evaluated in SPF chickens. Materials and Methods: I...

The immunogenicities and efficacies of a licensed diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine and the same vaccine formulated in a liposome/oil emulsion adjuvant were compared in a mouse model of pertussis respiratory infection. A single dose of the liposome/oil emulsion-adjuvanted vaccine produced significantly higher antibody levels than one dose of the licens...

abstract background and aims: vaccination of poultry has a major impact on the prevention and control of avian influenza viruses. nanobiotechnology techniques provide a new approach for improvement of influenza vaccine efficacy. in this study, efficacy of an inactivated nano-adjuvant vaccine developed based on an endemic h9n2 virus was evaluated in spf chickens. materials and methods: in each t...

Received: Revised: Accepted: Online available: October 10, 2015 December 31, 2015 January 02, 2016 January 13, 2016 Hemorrhagic septicemia is an important disease of cattle and buffaloes in Asia, particularly the South and Southeast Asia. Since outbreaks lead to numerous deaths and severe economic loss, control by vaccination is extremely important. However, the current use of broth vaccine for...

Small groups of volunteers were inoculated intranasally with live-attenuated, and parenterally with detergent-split-saline or with whole-virus-oil-adjuvant influenza A2/HK (H3N2) vaccines after the prevalence of Hong Kong strains. Antibody titres in nasal secretions and serum were measured by HI, antineuraminidase and neutralization tests. The oil adjuvant vaccine produced large rises in antibo...

CAMERON, C. M., 1980. Effective immunization of lambs against enterotoxaemia. Onderstepoort Journal of Veterinary Research, 47, 287-289 (1980). In contrast to adult sheep, 2to 3-month-old lambs do not respond well to a single injection of Clostridium perfringens Type D oil adjuvant epsilon toxoid. This unresponsiveness can be overcome, however, by administering 2 injections of oil adjuvant vacc...

an adjuvant is a substance that is added to a vaccine to increase the body's immune response to the vaccine. vaccines containing adjuvants are tested for safety in clinical trials before they are licensed for used. the basic action of adjuvants is stimulating adaptive immune responses. adjuvants, recently licensed for human utlization, involve alum squalane oil or water emulsion, influenza viro...

Infectious bovine rhinotracheitis (IBR) virus was grown in Madin Darby bovine kidney (MDBK) cell line using a roller culture system for its large-scale production. Optimum multiplicity of infection (MOI) of 1:750 was found to give consistent virus yield. To determine the appropriate payload, three batches of antigen with virus titres ranging from 10(8.37) to 10(6.37) TCID50 per ml were used to ...

In the present study the effect of the locally produced genetic adjuvant of ginea pig specific CpG-motif-containing oligodeoxynucleotide (CpG-ODN) in an inactivated FMD virus vaccine was evaluated. Boosting the ginea pigs with FMD vaccine along with CpG-ODN adjuvant produced relatively higher ratio (5-fold) of FMDV-specific IgG2a / IgG1 than those vaccinated in the absence of CpG-ODN. The neutr...