The aim of the present study was to assess the activity of membrane enzymes: alanine aminopeptidase (AAP), gamma-glutamyltransferase (GGT) and trehalase in amniotic fluid of women who smoke cigarettes during pregnancy complicated by idiopathic oligohydramnios or premature rupture of the membranes (PROM). The enzyme activity was measured between 22 and 31 (group A) and between 32 and 39 (group B...

background:   objective: to determine pregnancy outcome of women with β-thalassemia minor.   materials and methods: in this retrospective, case-control study in two universities affiliated hospitals in shiraz, all pregnancies occurred between 2006 and 2008 were included. patients were divided in two groups regarding the presence of β-thalassemia minor. patients in case and control groups were m...

OBJECTIVE To investigate whether isolated oligohydramnios at term is associated with increased rates of perinatal morbidity and mortality and whether induction of labor in term pregnancies with isolated oligohydramnios is superior to conservative management in reducing perinatal morbidity and mortality. STUDY DESIGN We searched databases from inception to May 2015. We included studies that ev...

Oligohydramnios is an ominous pregnant complication with high perinatal morbidity and mortality of 80%-90%, if it was observed in second trimester. However, there is no promising modality to cure it at that period. In this case, heparin therapy was successful in an early onset extreme oligohydramnios.

BACKGROUND β-thalassemia is the most common hereditary disease in Iran and more than 2 million carriers of the β-thalassemia mutant gene are living in this country. OBJECTIVE To determine pregnancy outcome of women with β-thalassemia minor. MATERIALS AND METHODS In this retrospective, case-control study in two universities affiliated hospitals in Shiraz, all pregnancies occurred between 200...

The results in the management of pregnant women in idiopathic oligohydramnios using monitoring of major parameters of the biophysical profile of the functional maternal biosystem – amniotic structures – the fetus are given in this article. It was established that prenatal prognosis could be objectively performed on the basis of the main estimations of heart rate variability, amniotic fluid inde...

To the best of our knowledge, there is no prospective trial study assessing the management of β-thalassemia by blood transfusion in pregnancy. The aim of this study was to investigate the effect of blood transfusion on maternal and neonatal outcomes in pregnant patients with beta thalassemia minor and intermedia. We did this randomized, single -blind, controlled clinical trial on 36 pregnant wo...

Objective: To evaluate the perinatal outcome in patients with isolated oligohydramnios. Design: A prospective study. Sample: 146 patients had isolated oligohydramnios. These were compared with those having AFI>5 cm (n=500). Methods: A prospective study was conducted from November 2012 to November 2014. Patients were divided into two groups (AFI>50 mm and ≤ 50 mm). The study inclusion criteria w...

BACKGROUND Oligohydramnios (reduced amniotic fluid) may be responsible for malpresentation problems, umbilical cord compression, concentration of meconium in the liquor, and difficult or failed external cephalic version. Simple maternal hydration has been suggested as a way of increasing amniotic fluid volume in order to reduce some of these problems. OBJECTIVES The objective of this review w...

Aquaporin 3 (AQP3) has been shown to be low in the amnion and chorion tissues of patients with oligohydramnios and that S. miltiorrhiza, a Chinese herbal medicine, results in increased AQP3 in human amniotic epithelial cells (hAECs). Here, we provide evidence for the involvement of the JNK pathway in AQP3 regulation in isolated oligohydramnios tissues in vitro, in hAECs derived from normal amni...