The activity of DNA polymerase I from Saccharomyces cerevisiae is inhibited, in a dose-dependent fashion, by the oncogenic ~3-blocker 1-(2-nitro-3-methyl-phenoxy)3-tert-butylamino-propan-2-ol (ZAMI 1305) and by the non-oncogen ic 8-blockers 1-(2-nitro-5-methyl-phenoxy) -3ter t -buty lamino-propan-2-ol (ZAMI 1327), atenolol, and propranolol, the lat ter having the highest inhibiting activity. Th...

After its discovery as oncogen and morphogen, studies on Wnt focused initially on its role in animal development. With the finding that the colorectal tumour suppressor gene APC is a negative regulator of the Wnt pathway in (colorectal) cancer, attention gradually shifted to the study of the role of Wnt signalling in the adult. The first indication that adult Wnt signalling controls stem cells ...

SourcesofMonoclonal Antibodies.HMB-50 was isolated as described using an extract of metastatic human malignant melanoma as the immunogen (25). HMB-50 is an IgG2a. Purified p973and monoclonal antibodies to p97 were provided by Drs. Joe Brown and Charles Estin, Oncogen, Seattle, WA, and antibodies to the Mr 250,000500,000 proteoglycan complex and ganglioside G03 provided by Drs. Karl-Enk and Inge...

The aim of this study was to determine the expression intensity of c-erbB-2 antigen in oral lichen planus and erosive form of oral lichen in 30 patients, and to compare the obtained results with the inflammation intensity i.e. hyperkeratosis. The examination of expression intensity of c-erbB-2 antigen was conducted through immunohistochemical analysis by APAAP method. Obtained reaction of exami...

With both nonradioactive and "*C-labeled dioxane, the effect of typical inducers and inhibitors of hepatic mixedfunction oxidases on the excretion of p-dioxane-2-one, the major urinary metabolite of dioxane, was studied. Pretreatment of rats with the inducers phénobarbital (PB), polychlorinated biphenyls (PCB), and, to a much lesser extent, 3-methylcholanthrene (MC) increased the metab olite e...