The Reformatsky reaction is the well-recognized carbon–carbon bond-forming reaction of α-halo esters with aldehydes or ketones in the presence of Zn metal to give β-hydroxy esters. Recently, it has been reported that Rhand Ni-catalyzed Reformatsky reaction, in which R2Zn (R = Me, Et) acts as the Zn source, reacted smoothly with carbonyl compounds and imines. Taking advantage of N-methylephedrin...

The addition of Grignard reagents or organolithium reagents to the SO2-surrogate DABSO generates a diverse set of metal sulfinates, suitable for direct conversion to sulfone products. The metal sulfinates can be trapped in situ with a wide range of C-electrophiles, including alkyl, allyl, and benzyl halides, epoxides, and (hetero)aryliodoniums.

nano tin dioxide was employed as a catalyst for efficient and facile preparation of pyran derivatives via the one-pot three component condensation reaction of various aldehydes with malononitrile and dimedone. chromene derivatives via the one-pot three component condensation reaction of various aldehyde with malononitrile and 4-hydroxycoumarin were also synthesized by this novel catalyst. the d...

phosphosulfonic acid (psa) was found to be an efficient catalyst for the one-pot three-component hantzsch condensation reaction of arylaldehydes, ethylacetoacetate and ammonium acetate to afford the corresponding 1,4-dihydropyridine and polyhydroquinoline derivatives in high yields. psa was also applied for the one-pot preparation of polyhydroquinolines via four-component reaction of arylaldehy...