PURPOSE To determine the underlying retinal micropathology in subclasses of autosomal dominant retinitis pigmentosa (ADRP) caused by rhodopsin (RHO) mutations. METHODS Patients with RHO-ADRP (n = 17, ages 6-73 years), representing class A (R135W and P347L) and class B (P23H, T58R, and G106R) functional phenotypes, were studied with optical coherence tomography (OCT), and colocalized visual th...

We report optical coherence tomography (OCT) findings in a 48 years old man with Leber’s idiopathic stellate neuroretinitis. Ophthalmoscopy of the right eye revealed serous retinal detachment (SRD) and marked hard exudates in the papillomacular region. Imaging with OCT revealed an accumulation of fluid in the outer nuclear layer (ONL), the outer plexiform layer (OPL) and the inner nuclear layer...

PURPOSE To determine the correlation between the prognosis of branch retinal artery obstruction (BRAO) and the foveal thickness or outer nuclear layer (ONL) thickness on optical coherence tomography (OCT). METHODS Twenty-one eyes (21 patients) in patients with resolved, non-complicated BRAO and a normal control of 10 eyes (10 volunteers) were used in this study. The average macular thickness,...

Quantifying the deformation of retinal tissue after injury is crucial in understanding and characterizing the functional effect of cellular changes. We present a novel method to compute multiple quantitative measures from a single set of retinal images collected with a confocal microscope. We automatically detect nuclei within the outer nuclear layer (ONL) in these images and based on the resul...

PURPOSE The aim of this study was to correlate different types of retinal morphologic alterations secondary to diabetic macular disease with their characteristic impact on retinal function. METHODS In the present cross-sectional study, 26 eyes of 26 diabetic patients with clinically significant macular edema were examined. All patients underwent complete standardized ophthalmologic examinatio...

INTRODUCTION Complement activation is thought to contribute to the pathogenesis of age-related macular degeneration (AMD), which may be mediated in part by para-inflammatory processes. We aimed to investigate the expression and localization of C3, a crucial component of the complement system, in the retina during the course of aging. METHODS SD rats were born and reared in low-light condition...

The functional organization and synaptic physiology of olfactory bulb glomeruli were studied in rat in vitro slice preparations stained with the voltage-sensitive dye RH-155. Optical signals were recorded with a 100-element photodiode array at high temporal resolution. Pharmacological and ionic manipulations were used to investigate synaptic responses to stimulation of the olfactory nerve layer...