breast cancer is the most common malignancy in women in many parts of the world. the risk factors for breast cancer cover a broad range of conditions, from age to complex genetic alterations. present data is showing an increase in the annual incidence rates of disease and it is ranked as the first recorded malignancies among iranian women after 1999. to study the association of reproductive and...

the male breast cancer (mbc) is a very rare neoplasm which accounts for 0.5-1% of the total cases of breast cancer. bilateral involvement is reported to occur in fewer than 2% of all the diagnosed cases of mbc, and synchronous tumors are very rare. because of its rarity, little is known about mbc etiology, its clinical findings and treatment. most patients present with a painless breast mass. t...

Background: Breast cancer is one of the most common malignancies among Iranian women; however, its clinicopathological feature is uncertain. We pioneered a genetic counseling program among patients with breast cancer and their families in Isfahan. This is the first report of this program. Methods: This was a descriptive cross-sectional study on women with breast cancer registered in Ala Cancer...

the present research is a field study in order to investigate scale and ways of doing breast self examination (bse). 270 nurses employed by the medical sciences university’s hospitals related to the ministry of health, and medical education in city of tehran are selected and involved in research on the basis of simple random sampling. the data collection tool was a protrayed questionnaire which...

Breast cancer is a heterogeneous malignancy; its age-specific incidence profile rises exponentially until menopause and increases more slowly thereafter, reflecting the superimposition of early-onset and late-onset breast cancer rates. While early-onset breast cancers largely represent inherited or early life transforming effects on immature mammary epithelium, late-onset breast cancers likely ...

BACKGROUND Estrogen plus progestin therapy increases breast cancer incidence and breast tenderness. Whether breast tenderness during estrogen plus progestin therapy is associated with breast cancer risk is uncertain. METHODS We analyzed data from the Women's Health Initiative Estrogen + Progestin Trial, which randomized postmenopausal women with an intact uterus to receive daily conjugated eq...

male breast cancer is a rare disease with an increasing trend. due to limited information especially about the genetic basis of the disease in iran and the lower age of its onset, the disease requires more attention. the aim of this study was to screen the male patients with breast cancer for brca mutations as well as tissue markers of estrogen receptor (er), progesterone receptor (pr), human e...

Japanese breast cancer families were collected and classified into the following 7 types according to the onset age and the distribution of other cancers in the family lines; early-onset type, late-onset type, familial breast-ovarian cancer type, familial breast-prostate cancer type, familial breast-thyroid cancer type, familial male and female breast cancer type and multiple primary cancer typ...

Neurofibromatosis type 1 (NF1), which may occur as an autosom-al dominant disorder, is caused by the absence of neurofibromin protein due to somatic mutations in the NF1 gene, and it has been associated with an increased risk of breast cancer. Herein we describe a family with two women affected by both NF1 and early-onset breast cancer. We evaluated whether the concomitance of NF1 and early-ons...