background anxiety is a physiological state characterized by cognitive, somatic, emotional, and behavioral components. there is some evidence in traditional medicine for the effectiveness of lettuce (lactuca sativa) in the treatment of anxiety in humans. objectives the present study investigated the effects of a hydro-alcoholic extract of lettuce on rat behavior in the elevated plus-maze (epm) ...

background medicinal plants with natural antioxidants have been shown to be beneficial in a variety of complications such as anxiety. the elevated plus-maze (epm) is one of the most widely used models to assess anxiety in small rodents. objectives this study was designed to characterize the anxiolytic-like activity of borago officinalis (linnaeus, family boraginaceae) or borage flowers extract,...

conclusions our results demonstrated that the extract of ob could induce anxiolytic effect in rats after 1 week oral administration. the effect of ob was not induced through changes in motor activity. further investigations are necessary for pharmacological providing of ob and better understanding of its anxiolytic properties and neurobiological mechanisms. results the results showed that after...

Introduction: Previous studies have shown that zinc deficiency and castration could increase anxiety, while administration of zinc or testosterone has anxiolytic effects. This study examined the effect of zinc chloride administration on anxiety in gonadectomized male rats. Methods: For this purpose, adult male Wistar rats (weighing 200-250 g) were castrated. One month after surgery, differe...

Vasoactive intestinal peptide (VIP) is a neuropeptide, which is widely distributed in the central nervous system and peripheral tissues, acting both as a neurotransmitter and neuromodulator. Despite its extensive expression in the hippocampus, amygdala and other limbic system structures, the effects of VIP on anxiety and depression have not yet been fully investigated. The aim of the present st...