We discuss the current state of knowledge related to the pathogenesis of myocardial stunning as well as the potential mechanisms responsible for the clinical presentation of myocardial stunning in hemodialysis patients. We suggest future research areas for this critical and clinically important condition in this high-risk patient population. In consideration of acute and chronic changes seconda...

Abstract Myocardial contusion (MC) is a note rare and potentially fatal complication of blunt chest trauma (BCT). The spectrum manifestations post–traumatic cardiac injury varies widely: from clinically silent injuries to severe reductions in function, myocardial hematomas, heart ruptures, life–threatening arrhythmias1. There no unique definition for this entity, the diagnostic criteria propose...

BACKGROUND Acidosis during early reperfusion is reported to be beneficial for myocardial stunning. We tested in 31 dogs the hypothesis that staged reperfusion is beneficial to myocardial stunning. METHODS AND RESULTS Contractile dysfunction was observed 3 hours after the onset of reperfusion after 15 minutes of occlusion of the coronary artery. In the staged reperfusion, pH of the coronary ve...

Jt is now well established that myocardial dysfunction, once thought to be indicative of irreversible tissue damage, is in many cases reversible. This has led to the concepts of myocardial "stunning"1'2 and "hibernation."3 In both of these conditions, myocardial function is reversibly compromised; in stunning, myocardial function is decreased in response to a previous ischemic insult, and blood...

To the Editor: The article by Feng et al1 caused a revolution in current thinking regarding the pathomechanism involved in myocardial stunning, in that it irrefutably proved that there is no causal link between troponin I (TnI) degradation and the transiently depressed contractile function after a brief ischemic episode. However, does this fact imply that there is no answer to the question of w...

We recently discovered an opioid peptide analgesic, 2',6'-dimethyltyrosine (Dmt)-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA), that can protect against ischemia-induced myocardial stunning. In buffer-perfused hearts, 30-min global ischemia followed by reperfusion resulted in a significant increase in norepinephrine (NE) overflow immediately upon reperfusion and significant decline in contractile force (...