One of the major causes of misdiagnosis of papilledema is buried drusen of the optic nerve head [1, 2]. Optic nerve drusen are calcified concretions of unknown etiology, located within the optic nerve head just anterior to the lamina cribrosa. As these concretions enlarge they may become visible ophthalmoscopically. When buried in the nerve head, they may cause difficulties in the ophthalmoscop...

PURPOSE To establish whether optic nerve head astrocytes express candidate molecules to sense tissue stretch. METHODS We used conventional PCR, quantitative PCR, and single-cell reverse transcription PCR (RT-PCR) to assess the expression of various members of the transient receptor potential (TRP) channel family and of the recently characterized mechanosensitive channels Piezo1 and 2 in optic...

A retrospective study of 737 consecutive necropsies yielded 15 cases of drusen of the optic nerve head, an incidence of 20-4 cases per thousand. This represents the highest incidence yet reported. The histopathological features of drusen of the nerve head included elevation of the nerve head, compression of optic nerve fibres, partial optic atrophy, cytoid bodies, disc haemorrhages, juxtapapill...

This case depicts an unusual presentation of septo-optic dysplasia. A four-year-old female presented with monocular nystagmus and temporal optic disc pallor in her left eye. Despite a normal sized optic nerve head, magnetic resonance imaging (MRI) showed a hypoplastic intraorbital and intracranial left optic nerve in the absence of a septum pellucidum. She was subsequently diagnosed with septo-...

Optic nerve head is part of the retina where ganglion cell axons exit the eye to form the optic nerve. Glaucomatous changes related to loss of the nerve fibers decrease the neuroretinal rim and expand the area and volume of the cup. Therefore optic nerve head evaluation is important for early diagnosis of glaucoma. This study implements the detection of the optic nerve head in retinal fundus im...

PURPOSE To determine if astrocyte processes label for actin and to quantify the orientation of astrocytic processes within the optic nerve head (ONH) in a rat glaucoma model. METHODS Chronic intraocular pressure (IOP) elevation was produced by episcleral hypertonic saline injection and tissues were collected after 5 weeks. For comparison, eyes with optic nerve transection were collected at 2 ...

The vascular aetiology of glaucoma hypothesizes that a compromised blood supply to the optic nerve head contributes to optic nerve head damage. Localized damage may occur when ocular perfusion deficits of the optic nerve head, the retina, the choroid or the retrobulbar vessels falls outside the normal range of autoregulation. This may be the result of systemic dysfunction (vasosclerosis, small ...

a 22 year-old woman presented with gradual visual loss in her right eye since 1990. medical and family histories were unremarkable. her visual acuity was 20/80 and 20/20 in right and left eyes respectively. slit lamp examination was quite normal with no relative afferent papillary defect.fundi of both eyes revealed subretinal lesion with optic nerve head involvement and subretinal fluid in papi...

Methods: Optical coherence tomographic images from 60 subjects (20 with ODE, 20 with ONHD, and 20 control subjects) were assessed qualitatively and quantitatively. Qualitative criteria for ODE included an elevated optic nerve head with smooth internal contour and subretinal hyporeflective space (SHYPS) with recumbent “lazy V” pattern. Optic nerve head drusen displayed a “lumpybumpy” internal op...

Impairments of autoregulation and neurovascular coupling in the optic nerve head play a critical role in ocular pathologies, especially glaucomatous optic neuropathy. We critically review the literature in the field, integrating results obtained in clinical, experimental, and theoretical studies. We address the mechanisms of autoregulation and neurovascular coupling in the optic nerve head, the...