BACKGROUND This report presents 13 years of experience with vasodilator therapy for primary pulmonary hypertension (PPH) in children. Two eras were involved: between 1982 and 1987, oral calcium channel blockers were the only agents available for long-term therapy; after 1987, prostacyclin (PGI2) has been available for long-term intravenous use. METHODS AND RESULTS Seventy-four children underw...

multicast routing is one of the most important services in multi radio multi channel (mrmc) wireless mesh networks (wmn). multicast routing performance in wmns could be improved by choosing the best routes and the routes that have minimum interference to reach multicast receivers. in this paper we want to address the multicast routing problem for a given channel assignment in wmns. the channels...

many appealing multicast services such as on-demand tv, teleconference, online games and etc. can benefit from high available bandwidth in multi-radio multi-channel wireless mesh networks. when multiple simultaneous transmissions use a similar channel to transmit data packets, network performance degrades to a large extant. designing a good multicast tree to route data packets could enhance the...

Lidocaine is a use-dependent sodium channel blocker that produces analgesia when administered intravenously to patients with neuropathic pain. This article reviews the role and limitations of intravenous lidocaine infusions for neuropathic pain. Lidocaine infusions rarely provide relief that persists significantly beyond the duration of the infusion. Diagnostically, systemic lidocaine may help ...

A 53-kDa protein from the outer sheath of the oral spirochete Treponema denticola was purified to homogeneity and shown to reconstitute channels in black lipid bilayer model membranes. The channel had a single-channel conductance of 1.8 nS in 0.1 M KCl, making this the largest porin channel observed to date (estimated diameter, 3.4 nm). Electron micrographs of 53-kDa-protein-containing outer sh...

Increased endogenous glucose production (EGP) is a hallmark of type 2 diabetes mellitus. While there is evidence for central regulation of EGP by activation of hypothalamic ATP-sensitive potassium (K(ATP)) channels in rodents, whether these central pathways contribute to regulation of EGP in humans remains to be determined. Here we present evidence for central nervous system regulation of EGP i...

using of nanofluids and ducts with corrugated walls are both supposed to enhance heat transfer, by increasing the heat transfer fluid conductivity and the heat transfer area respectively. use of a diverging duct with a jet at inlet section may further increase heat transfer by creating recirculation zones inside the duct. in this work two-dimensional incompressible laminar flow of a nanofluid e...