lichen planus (lp) is a chronic inflammatory disease of probable immune-based etiology. the pathogenesis of lp is unclear, but apoptotic changes in epidermal (epithelial) cells have been reported. destruction of the basal cell layer is observed and many changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium. the aim of this study was to evaluate and co...

Aim of the present investigation was to analyse the possible malignant transformation of oral lichen planus to carcinoma, especially in the atrophic erosive forms and those displaying plaques involving the top of the tongue. A review has been made of the literature, from 1986 to the present day. This search outlines the relationship between oral lichen planus, hepatitis C virus infection, Epste...

BACKGROUND Although oral lichen planus has been classified by the World Health Organization (WHO) as a potentially malignant disorder, such classification is still the target of much controversy. AIM To evaluate the cell proliferation rate in oral lichen planus, comparing it to the rate observed in epithelial dysplasia and oral squamous cell carcinoma, aiming at indications which might indica...

OBJECTIVE Lichen planus and lichenoid lesions affecting the oral cavity show similar clinico-pathological features creating a diagnostic dilemma. Hence, the aim of the present study was to establish a clinical and histopathological correlation in the diagnosis of oral lichen planus, based on the modified WHO diagnostic criteria of oral lichen planus and oral lichenoid lesions proposed by Van de...

background and aims. standard treatment of oral lichen planus (olp) includes topical or systemic corticosteroids that have many adverse effects. a trend toward alternative natural or herbal drugs has attended recently. this study was conducted to evaluate the effect of quercetin in treatment of erosive-atrophic olp. materials and methods. thirty patients participated in this randomized clinical...

background: normal salivary function is considered to be critical for the maintenance of healthy oral mucosa. oral fluids provide an easily available, non-invasive medium for the diagnosis of wide range of diseases and clinical situations. the objective of this study was to estimate and compare salivary nitric oxide levels in patients with oral lichen planus and healthy individuals. aim: to est...

background and aims. oral lichen planus is a relatively common chronic oral mucosal disease of unknown etiology. regarding numerous studies on the immunologic factors involved in the etiology of lichen planus, the present study evaluated the serum interleukin-17 (il-17) level in patients with erosive and non-erosive oral lichen planus. materials and methods. this descriptive analytical study in...

OBJECTIVES The purpose of this study was to evaluate the expression of cdk4 and p16, the proteins implicated in hyperproliferation and arrest in oral lichen planus and to compare their expression in erosive and non-erosive oral lichen planus and with normal mucosa and oral squamous cell carcinoma. MATERIAL AND METHODS Analysis of cdk4 and p16 expression was done in 43 erosive oral lichen plan...

Oral lichen planus which is one of the most common oral mucosal diseases in adults, it has been rarely described in children. There are very reports in the literature regarding oral lichen planus in children, here we report a case of intraoral lesions of lichen planus. Lichen planus should be considered in the differential diagnosis of hyperkeratotic or erosive lesions of the oral mucosa in chi...