To analyze the clinical symptoms and signs in cases of oral submucous fibrosis which has transformed into squamous cell carcinoma, twenty-nine patients with squamous cell carcinoma correlated with oral submucous fibrosis, leukoplakia, lichen planus were taken biopsy for positive diagnosis. The clinical and pathological diagnosis of oral submucous fibrosis depended on clinical and pathological d...

The Study was conducted to evaluate the prevalence of Use of tobacco & its associated products & Oral Sub Mucous Fibrosis among teenagers. It was conducted on 750 school going teenagers of Dehradun city. Results of the study showed that 34.1% of the study subjects used tobacco & its associated products & among them 14.2% of Oral Sub Mucous Fibrosis cases were identified. Association between typ...

Background Podoplanin is a type I transmembrane sialomucin-like glycoprotein that is specifically expressed in lymphatic endothelial cells. Studies have shown that assessment of podoplanin expression in the epithelial cells can be used to predict the malignant transformation of potentially malignant disorders and the metastatic tendency of primary head and neck squamous cell carcinoma. The aim ...

Objectives: To determine the frequency of micronucleated cells and micronuclei in oral submucous fibrosis patients and to compare with healthy individuals. Study design: Twenty patients with oral submucous fibrosis and twenty age-sex-matched healthy individuals as control group participated in this study. Exfoliated cells were obtained by scraping from right and left buccal mucosa and were scre...

Oral submucous fibrosis is a chronic debilitating disease characterized by gradually increasing fibrosis of the oral cavity and pharynx, mainly the buccal mucosa, resulting in trismus. The highest incidence of oral submucous fibrosis is seen in South India due to various deleterious habits. In spite of the numerous medical modalities employed in the management of oral submucous fibrosis, occasi...

Oral Submucous fibrosis is a chronic progressive debilitating disease and often considered to be a potentially malignant disorder. Development of epithelial dysplasia in oral sub mucous fibrosis is debatable and the role of epithelium and connective tissue bed in its initiation, progression and promotion had been studied by various authors. Changes in epithelium of oral sub mucous fibrosis are ...

statement of the problem: soft tissue reactive lesions are the most common lesions of the oral cavity. although many studies have shown the interaction of mast cells with fibroblasts and their participation in fibrosis, the role of mast cells in these lesions is not well understood. purpose: the aim of this study was to evaluate the mast cells (mcs) count in oral soft-tissue reactive lesions in...

Oral submucous fibrosis-a chronic disseminated intravascular coagulation syndrome with local coagulopathy EDITOR,-We have read the leading article in Gut with great interest. (Gut 1992; 33: 4-6). We were, however, disappointed as the work on oral submucous fibrosis published in Indian journals' and the American Journal of Clinical Patholog/ has not been covered by the authors. After working for...

Oral submucous fibrosis (OSF) is a high risk precancerous condition characterized by changes in the connective tissue fibers of the lamina propria and deeper parts leading to stiffness of the mucosa and restricted mouth opening. Patients with severe cases have distinct difficulties in chewing, swallowing and speaking. It predominantly occurs in Indians and other population of the Indian subcont...

BACKGROUND Oral submucous fibrosis (OSMF) is a progressive disorder affecting the oral mucosa. OSMF predominantly seen in South-east Asian countries. There are some biochemicals parameters which are modify in oral submucous fibrosis; this alteration can be used as a tool for diseases progress and avert malignant transformation. AIMS AND OBJECTIVES The aim of this study is to evaluate the seru...